|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCC7
gptkb:LFS1
gptkb:TRP53
P53
|
|
gptkbp:approvedBy
|
gptkb:tumor_protein_p53
|
|
gptkbp:approvedSymbol
|
gptkb:TP53
|
|
gptkbp:associatedWith
|
gptkb:Li-Fraumeni_syndrome
various cancers
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:12679
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:12679
|
|
gptkbp:isMutatedIn
|
many human cancers
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:location
|
17p13.1
|
|
gptkbp:locusType
|
gene with protein product
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trp53
|
|
gptkbp:orthologInZebrafish
|
tp53
|
|
gptkbp:partOf
|
p53 signaling pathway
|
|
gptkbp:previousSymbols
|
gptkb:BCC7
gptkb:LFS1
P53
|
|
gptkbp:product
|
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:proteinFamily
|
gptkb:p53_family
|
|
gptkbp:RefSeq
|
gptkb:NM_000546
|
|
gptkbp:regulates
|
gptkb:ATR
gptkb:p14ARF
gptkb:p63
gptkb:p73
gptkb:CASP8
gptkb:CASP9
gptkb:SIRT1
gptkb:USP7
gptkb:CDKN1A_(p21)
gptkb:FAS
gptkb:PI3K
gptkb:SP1
gptkb:CBP/p300
gptkb:RB1
gptkb:BAX
gptkb:GADD45
gptkb:NOXA
gptkb:PUMA
gptkb:NF-kB
gptkb:c-Myc
gptkb:PKC
gptkb:JNK
gptkb:p38_MAPK
gptkb:PLK1
gptkb:DR5
gptkb:AKT
gptkb:AMPK
gptkb:ERK
gptkb:GSK3
gptkb:mTOR
gptkb:BRCA1
gptkb:CDK2
gptkb:E2F1
gptkb:BCL2
gptkb:BRCA2
gptkb:STAT3
gptkb:CASP3
gptkb:CHK2
gptkb:CK1
gptkb:E2F
gptkb:CDK5
gptkb:CK2
gptkb:14-3-3σ
apoptosis
ATM
DNA repair
angiogenesis
senescence
cell cycle arrest
APAF1
Aurora kinase A
Aurora kinase B
CDKN2A (p16)
HIPK2
MDM2-p53 feedback loop
PRMT5
SET7/9
Wip1
|
|
gptkbp:target
|
gptkb:MDM2
gptkb:MDM4
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:VDR
|
|
gptkbp:bfsLayer
|
7
|