|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
environmental stress
pro-inflammatory cytokines
dual phosphorylation on threonine and tyrosine
|
|
gptkbp:alternativeName
|
gptkb:MAPK14
gptkb:Mitogen-activated_protein_kinase_14
gptkb:CSBP
gptkb:SAPK2a
RK
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:MAPK14_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:function
|
signal transduction
inflammatory response
cellular response to stress
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p38 MAPK
|
|
gptkbp:inhibitedBy
|
gptkb:SB203580
gptkb:BIRB_796
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell cycle regulation
inflammation
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.31
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:molecularWeight
|
approximately 38 kDa
|
|
gptkbp:orthologIn
|
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
gptkb:MAPK14
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:HSP27
gptkb:MAPKAPK2
transcription factors
|
|
gptkbp:regulates
|
cell survival
gene expression
cytokine production
|
|
gptkbp:relatedTo
|
gptkb:JNK
gptkb:ERK
|
|
gptkbp:structure
|
serine/threonine kinase domain
|
|
gptkbp:subunit
|
gptkb:MAPK_pathway
|
|
gptkbp:target
|
cancer therapeutics
anti-inflammatory drugs
autoimmune disease drugs
|
|
gptkbp:bfsParent
|
gptkb:MAP_kinase
gptkb:mitogen-activated_protein_kinase
|
|
gptkbp:bfsLayer
|
6
|