|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
p35
p39
|
|
gptkbp:associatedWith
|
gptkb:cancer
neuronal apoptosis
tau phosphorylation
|
|
gptkbp:cofactor
|
p35
p39
|
|
gptkbp:discoveredBy
|
James Woodgett
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:EC_number
|
2.7.11.22
|
|
gptkbp:encodedBy
|
CDK5 gene
|
|
gptkbp:fullName
|
Cyclin-dependent kinase 5
|
|
gptkbp:function
|
cell cycle regulation
phosphorylation of proteins
regulation of neuronal development
|
|
gptkbp:gene
|
gptkb:CDK5
|
|
gptkbp:HGNC_ID
|
1771
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK5
|
|
gptkbp:inhibitedBy
|
gptkb:roscovitine
dinaciclib
|
|
gptkbp:involvedIn
|
gptkb:Alzheimer's_disease
neurodegeneration
synaptic function
neuronal migration
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q36.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
neurons
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:OMIM
|
603317
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Cdk5
rat Cdk5
|
|
gptkbp:PDB
|
1UNL
|
|
gptkbp:phosphorylates
|
gptkb:neurofilament_proteins
DARPP-32
CRMP2
MAPT (tau protein)
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
apoptosis
cell migration
neurite outgrowth
cell adhesion
|
|
gptkbp:UniProtID
|
Q00535
|
|
gptkbp:bfsParent
|
gptkb:CDK_kinases
gptkb:CAIL2
|
|
gptkbp:bfsLayer
|
7
|