|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:alias
|
gptkb:MYC
gptkb:bHLHe39
gptkb:proto-oncogene_c-Myc
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:binds
|
E-box DNA sequence
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
|
gptkb:MYC_gene
|
|
gptkbp:Entrez_Gene_ID
|
4609
ENSG00000136997
|
|
gptkbp:formsComplexWith
|
gptkb:MAX_protein
|
|
gptkbp:formsHeterodimerWith
|
gptkb:MAX_protein
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell cycle
regulation of cell differentiation
regulation of cell growth
regulation of cellular transformation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Myc
|
|
gptkbp:involvedIn
|
gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
colorectal cancer
leukemia
melanoma
multiple myeloma
pancreatic cancer
prostate cancer
hepatocellular carcinoma
gastric cancer
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:v-Myc
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:PDB
|
1NKP
|
|
gptkbp:phosphorylates
|
gptkb:Serine_62
gptkb:Threonine_58
|
|
gptkbp:regulates
|
cell proliferation
transcription
metabolism
cellular senescence
angiogenesis
cell migration
DNA replication
mitosis
cellular metabolism
cell adhesion
ribosome biogenesis
microRNA expression
telomerase activity
|
|
gptkbp:target
|
gptkb:siRNA
antisense oligonucleotides
small molecule inhibitors
therapeutic inhibitors
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:The_Reprogramming_of_Differentiated_Cells
|
|
gptkbp:bfsLayer
|
5
|