Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:p53
gptkb:transformation_related_protein_53 |
| gptkbp:associatedWith |
spontaneous tumor formation in mice
|
| gptkbp:biologicalProcess |
transcription factor
|
| gptkbp:discoveredBy |
gptkb:Arnold_Levine
|
| gptkbp:discoveredIn |
1979
|
| gptkbp:encodes |
gptkb:p53_protein
|
| gptkbp:Entrez_Gene_ID |
22059
|
| gptkbp:expressedIn |
various mouse tissues
|
| gptkbp:function |
tumor suppressor
|
| https://www.w3.org/2000/01/rdf-schema#label |
Trp53
|
| gptkbp:length |
390 amino acids
|
| gptkbp:locatedOnChromosome |
mouse chromosome 11
|
| gptkbp:mutationAssociatedWith |
nonsense
deletion missense increased cancer risk frameshift |
| gptkbp:organism |
gptkb:Mus_musculus
|
| gptkbp:orthologIn |
TP53 (human)
|
| gptkbp:product |
gptkb:p53
tetramer |
| gptkbp:proteinFamily |
DNA-binding domain
oligomerization domain transactivation domain |
| gptkbp:regulates |
gptkb:ATM_kinase
gptkb:Mdm2 gptkb:ARF gptkb:Tigar gptkb:Puma gptkb:Bax gptkb:Noxa apoptosis DNA repair phosphorylation cell cycle senescence methylation dephosphorylation sumoylation ubiquitination acetylation deubiquitination Chk2 Cyclin G1 Gadd45 deacetylation demethylation p21 (Cdkn1a) |
| gptkbp:requires |
genomic stability
response to DNA damage prevention of tumorigenesis |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm mitochondria |
| gptkbp:usedIn |
apoptosis research
genetic studies cell cycle research DNA damage response studies mouse cancer models |
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
6
|