|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:p53
gptkb:transformation_related_protein_53
|
|
gptkbp:associatedWith
|
spontaneous tumor formation in mice
|
|
gptkbp:biologicalProcess
|
gptkb:transcription_factor
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodes
|
gptkb:p53_protein
|
|
gptkbp:Entrez_Gene_ID
|
22059
|
|
gptkbp:expressedIn
|
various mouse tissues
|
|
gptkbp:function
|
gptkb:tumor_suppressor
|
|
gptkbp:length
|
390 amino acids
|
|
gptkbp:locatedOnChromosome
|
mouse chromosome 11
|
|
gptkbp:mutationAssociatedWith
|
nonsense
deletion
missense
increased cancer risk
frameshift
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
TP53 (human)
|
|
gptkbp:product
|
gptkb:p53
tetramer
|
|
gptkbp:proteinFamily
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:regulates
|
gptkb:ATM_kinase
gptkb:Mdm2
gptkb:ARF
gptkb:Tigar
gptkb:Puma
gptkb:Bax
gptkb:Noxa
apoptosis
DNA repair
phosphorylation
cell cycle
senescence
methylation
dephosphorylation
sumoylation
ubiquitination
acetylation
deubiquitination
Chk2
Cyclin G1
Gadd45
deacetylation
demethylation
p21 (Cdkn1a)
|
|
gptkbp:requires
|
genomic stability
response to DNA damage
prevention of tumorigenesis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:usedIn
|
apoptosis research
genetic studies
cell cycle research
DNA damage response studies
mouse cancer models
|
|
gptkbp:bfsParent
|
gptkb:chromosome_7_(mouse)
gptkb:TP53_gene
gptkb:HGNC:11762
gptkb:NP_031401
gptkb:TP53
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trp53
|