|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:pRb
gptkb:retinoblastoma-associated_protein
RB
|
|
gptkbp:associatedWith
|
gptkb:retinoblastoma
bladder cancer
Small Cell Lung Cancer
osteosarcoma
|
|
gptkbp:discoveredBy
|
gptkb:Stephen_H._Friend
gptkb:Thaddeus_Dryja
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
gptkb:retinoblastoma_protein
|
|
gptkbp:Entrez_Gene_ID
|
5925
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
retinoblastoma patients
|
|
gptkbp:fullName
|
gptkb:Retinoblastoma_1
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
9884
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RB1
|
|
gptkbp:inheritance
|
autosomal dominant
|
|
gptkbp:inhibitedBy
|
gptkb:E2F_transcription_factors
|
|
gptkbp:interactsWith
|
gptkb:MDM2
gptkb:BRCA1
gptkb:Cyclin_D1
gptkb:DP1
gptkb:E2F1
gptkb:HDAC1
gptkb:p53
|
|
gptkbp:length
|
928 amino acids
|
|
gptkbp:locatedOnChromosome
|
13q14.2
|
|
gptkbp:lossOfFunctionLeadsTo
|
uncontrolled cell proliferation
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
germline
hereditary retinoblastoma
increased cancer risk
somatic
sporadic retinoblastoma
|
|
gptkbp:OMIM
|
614041
|
|
gptkbp:orthologInMouse
|
gptkb:Rb1
|
|
gptkbp:phosphorylates
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:proteinFamily
|
C-terminal domain
pocket domain
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
cell cycle
G1/S cell cycle transition
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:bfsParent
|
gptkb:Canary_Wharf_Pier
gptkb:Meteor_Clipper
gptkb:Woolwich_(Royal_Arsenal)_Pier
|
|
gptkbp:bfsLayer
|
5
|