|
gptkbp:instance_of
|
gptkb:DNA
|
|
gptkbp:associated_with
|
gptkb:Oncology
osteosarcoma
|
|
gptkbp:clinical_trial
|
tumorigenesis
|
|
gptkbp:discovered_by
|
gptkb:David_A._Knudson
|
|
gptkbp:diseases
|
gptkb:familial_retinoblastoma
gptkb:hereditary_retinoblastoma
gptkb:neurofibromatosis_type_1
gptkb:sporadic_retinoblastoma
gptkb:Oncology
gptkb:Chondrichthyes
gptkb:Kaposi's_sarcoma
gptkb:non-Hodgkin_lymphoma
gptkb:pancreatic_cancer
gptkb:cervical_cancer
gptkb:Wilms_tumor
gptkb:neuroblastoma
ovarian cancer
liver cancer
retinal dysplasia
esophageal cancer
small cell lung cancer
bladder cancer
head and neck cancer
non-hereditary retinoblastoma
retinoblastoma predisposition syndrome
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:genetic_studies
|
deletion
point mutation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RB1
|
|
gptkbp:interacts_with
|
gptkb:cyclin-dependent_kinases
E2 F transcription factors
|
|
gptkbp:involved_in
|
cell cycle regulation
|
|
gptkbp:is_expressed_in
|
retinal cells
neuronal cells
|
|
gptkbp:located_in
|
chromosome 13
|
|
gptkbp:orthologs
|
gptkb:mouse
zebrafish
rat
|
|
gptkbp:pathway
|
cell cycle pathway
p53 signaling pathway
|
|
gptkbp:role
|
apoptosis
cell proliferation
|
|
gptkbp:bfsParent
|
gptkb:Red_Bull_Racing_Team
gptkb:hepatocellular_carcinoma
gptkb:Red_Bull_Racing
|
|
gptkbp:bfsLayer
|
5
|