Statements (113)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:pancreatic_cancer ovarian cancer increased risk of skin cancer increased risk of cervical cancer fallopian tube cancer male breast cancer peritoneal cancer increased risk of liver cancer increased risk of Hodgkin lymphoma increased risk of adrenocortical carcinoma increased risk of biliary tract cancer increased risk of bladder cancer increased risk of brain tumors increased risk of colorectal cancer increased risk of endometrial cancer increased risk of esophageal cancer increased risk of head and neck cancers increased risk of kidney cancer increased risk of laryngeal cancer increased risk of leukemia increased risk of melanoma increased risk of mesothelioma increased risk of multiple myeloma increased risk of neuroendocrine tumors increased risk of non-Hodgkin lymphoma increased risk of ovarian clear cell carcinoma increased risk of ovarian endometrioid carcinoma increased risk of ovarian germ cell tumors increased risk of ovarian mixed tumors increased risk of ovarian mucinous carcinoma increased risk of ovarian neuroendocrine tumors increased risk of ovarian sarcoma increased risk of ovarian serous carcinoma increased risk of ovarian sex-cord stromal tumors increased risk of ovarian small cell carcinoma. increased risk of pancreatic neuroendocrine tumors increased risk of soft tissue sarcoma increased risk of stomach cancer increased risk of testicular cancer increased risk of thyroid cancer increased risk of ovarian transitional cell carcinoma increased risk of ovarian low malignant potential tumors |
| gptkbp:breeding_range |
13q13.1
|
| gptkbp:case_analysis |
gptkb:Association_for_Molecular_Pathology_v._Myriad_Genetics
|
| gptkbp:clinical_trial |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
high risk for breast cancer high risk for ovarian cancer |
| gptkbp:code |
gptkb:protein
tumor suppressor protein |
| gptkbp:discovered_by |
gptkb:1995
gptkb:Mary-Claire_King gptkb:Michael_Stratton |
| gptkbp:diseases |
gptkb:Oncology
gptkb:anemia ovarian cancer fallopian tube cancer male breast cancer peritoneal cancer |
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_studies |
increased cancer risk
frameshift mutation missense mutation nonsense mutation increases cancer risk |
| gptkbp:has_impact_on |
treatment decisions
|
| gptkbp:has_role |
tumor suppressor
|
| gptkbp:has_variants |
BRCA2 3036dup A
BRCA2 6174del T |
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA2
|
| gptkbp:initiated_by |
cell proliferation
tumor growth |
| gptkbp:interacts_with |
gptkb:RAD51
|
| gptkbp:invention |
gptkb:Myriad_Genetics
|
| gptkbp:involved_in |
DNA repair
cell cycle regulation homologous recombination |
| gptkbp:is_expressed_in |
breast tissue
ovarian tissue |
| gptkbp:is_found_in |
gptkb:humans
|
| gptkbp:is_involved_in |
DNA damage response
|
| gptkbp:is_linked_to |
gptkb:Oncology
gptkb:hereditary_breast_and_ovarian_cancer_syndrome stomach cancer |
| gptkbp:is_located_in |
chromosome 13
|
| gptkbp:is_part_of |
cancer genetics
|
| gptkbp:is_recognized_as |
gptkb:1995
familial breast cancer cases |
| gptkbp:is_regulated_by |
hormones
|
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_tested_for |
genetic mutations
|
| gptkbp:located_in |
chromosome 13
|
| gptkbp:mutation_types |
frameshift mutations
nonsense mutations |
| gptkbp:mutations_lead_to |
increased cancer risk
increased risk of breast cancer |
| gptkbp:nutritional_value |
BRCA2 protein
|
| gptkbp:orthologs |
other species
|
| gptkbp:part_of |
gptkb:BRCA_family
|
| gptkbp:pathway |
DNA double-strand break repair
|
| gptkbp:promoter |
gptkb:BRCA2
|
| gptkbp:promotes |
genomic stability
|
| gptkbp:related_to |
gptkb:BRCA1
|
| gptkbp:research_focus |
cancer genetics
|
| gptkbp:risk_factor |
gptkb:Oncology
gptkb:pancreatic_cancer |
| gptkbp:role |
homologous recombination
|
| gptkbp:seed_dispersal |
tumor suppressor gene
|
| gptkbp:targets |
genetic testing
|
| gptkbp:test_available_for |
genetic testing
|
| gptkbp:bfsParent |
gptkb:pancreatic_cancer
|
| gptkbp:bfsLayer |
4
|