cellular tumor antigen p53

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:p53 gptkb:tumor_protein_p53
gptkbp:conservedIn	gptkb:Caenorhabditis_elegans gptkb:Drosophila_melanogaster mammals vertebrates
gptkbp:discoveredBy	gptkb:Arnold_Levine gptkb:David_Lane
gptkbp:discoveredIn	1979
gptkbp:encodedBy	gptkb:TP53_gene
gptkbp:Entrez_Gene_ID	7157 ENSG00000141510
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	tumor suppressor transcription factor
https://www.w3.org/2000/01/rdf-schema#label	cellular tumor antigen p53
gptkbp:interactsWith	gptkb:BAX gptkb:p21 gptkb:MDM2 gptkb:BRCA1 ATM
gptkbp:locatedOnChromosome	17p13.1
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	53 kDa
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:Li-Fraumeni_syndrome
gptkbp:OMIM	191170
gptkbp:PDB	1TUP
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:regulates	gptkb:CDKN1A gptkb:BAX gptkb:GADD45 gptkb:NOXA gptkb:PUMA gptkb:MDM2 apoptosis DNA repair cell cycle senescence genomic stability
gptkbp:structure	tetramer
gptkbp:target	gptkb:nutlin-3 gptkb:RITA gptkb:MI-219 anticancer drugs APR-246 MDM2 inhibitors PRIMA-1
gptkbp:UniProtID	P04637
gptkbp:bfsParent	gptkb:NP_005017.2
gptkbp:bfsLayer	6