Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
enzyme
|
| gptkbp:action |
growth factors
|
| gptkbp:associatedWith |
diabetes
cancer inflammation |
| gptkbp:diedIn |
glucose metabolism
immune response lipid metabolism neuronal signaling angiogenesis |
| gptkbp:established |
gptkb:Dr._William_C._S._Cho
|
| gptkbp:function |
phosphorylates phosphatidylinositol
|
| gptkbp:hasPerformedAt |
PI3Kα
PI3Kβ PI3Kγ PI3Kδ |
| https://www.w3.org/2000/01/rdf-schema#label |
PI3K
|
| gptkbp:involvedIn |
metabolism
aging apoptosis cell differentiation cell growth cell proliferation cellular stress clinical trials combination therapy drug development hypoxia neurodegenerative diseases signal transduction autoimmune diseases metabolic syndrome obesity stress response fibrosis cardiovascular diseases tumorigenesis cell survival pharmacogenomics targeted therapy tumor microenvironment endocytosis chronic inflammation precision medicine cell migration metastasis therapeutic targets exocytosis therapeutic resistance neoplasia cancer immunotherapy hormonal signaling vascularization biomarker_discovery |
| gptkbp:isActiveIn |
PI3K_inhibitors
|
| gptkbp:locatedIn |
cell membranes
|
| gptkbp:regulates |
AKT signaling pathway
|