|
gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:activatedBy
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gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
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gptkbp:discoveredBy
|
gptkb:Lewis_Cantley
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:EC_number
|
2.7.1.153
|
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gptkbp:fullName
|
gptkb:protein
|
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gptkbp:function
|
phosphorylates the 3' hydroxyl group of the inositol ring of phosphatidylinositol
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|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K
|
|
gptkbp:inhibitedBy
|
gptkb:LY294002
gptkb:wortmannin
|
|
gptkbp:involvedIn
|
differentiation
survival
cell growth
intracellular signaling
motility
proliferation
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|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
inflammatory diseases
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:product
|
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
|
gptkbp:proteinFamily
|
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
|
|
gptkbp:relatedTo
|
gptkb:AKT_pathway
gptkb:mTOR_pathway
|
|
gptkbp:subunit
|
catalytic subunit
regulatory subunit
|
|
gptkbp:type
|
gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
|
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gptkbp:bfsParent
|
gptkb:RAS
gptkb:protein
|
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gptkbp:bfsLayer
|
4
|