|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
DNA-binding domain
dimerization domain
transactivation domain
marked box domain
|
|
gptkbp:formsComplexWith
|
gptkb:DP_proteins
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:gene
|
gptkb:E2F
|
|
gptkbp:hasMember
|
gptkb:E2F2
gptkb:E2F3
gptkb:E2F4
gptkb:E2F5
gptkb:E2F6
gptkb:E2F7
gptkb:E2F8
gptkb:E2F1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E2F
|
|
gptkbp:inhibitedBy
|
gptkb:pRB
p107
p130
|
|
gptkbp:interactsWith
|
gptkb:retinoblastoma_protein
|
|
gptkbp:locatedOn
|
chromosome 20q11.2 (E2F1 in humans)
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
DNA repair
cell cycle
tumor suppression
oncogenesis
p53 pathway
DNA synthesis
S phase entry
ARF gene
Bcl-2 family genes
DNA polymerase genes
MCM genes
cdc6 gene
cyclin genes
thymidine kinase gene
|
|
gptkbp:relatedTo
|
gptkb:cancer
development
cellular senescence
immune response
neurogenesis
|
|
gptkbp:bfsParent
|
gptkb:WAF1_gene
gptkb:p21
|
|
gptkbp:bfsLayer
|
6
|