|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:Apaf-1
gptkb:cytochrome_c
|
|
gptkbp:alias
|
gptkb:ICE-LAP6
gptkb:MCH6
gptkb:apoptotic_protease_Mch-6
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:cleavage
|
gptkb:caspase-3
gptkb:caspase-7
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
gptkb:caspase-9_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000132906
842
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:caspase_9
|
|
gptkbp:function
|
initiator caspase in apoptosis
cysteine-aspartic protease activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0004197 (cysteine-type endopeptidase activity)
GO:0006915 (apoptotic process)
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:1509
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CASP9
|
|
gptkbp:involvedIn
|
cell death
cytochrome c-mediated apoptosis
intrinsic apoptotic signaling pathway
|
|
gptkbp:length
|
416
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.21
1
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:OMIM
|
602234
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Rattus norvegicus (rat)
|
|
gptkbp:PDB
|
gptkb:2AR9
1JXQ
1NW9
|
|
gptkbp:proteinFamily
|
gptkb:CARD_domain
gptkb:caspase_domain
gptkb:caspase_family
|
|
gptkbp:regulates
|
regulated by phosphorylation
inhibited by XIAP
|
|
gptkbp:subcellularLocation
|
mitochondria
cytosol
|
|
gptkbp:UniProtID
|
gptkb:P55211
|
|
gptkbp:bfsParent
|
gptkb:Caspase-9
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|