|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FLICE
gptkb:MACH
gptkb:Mch5
gptkb:ALPS2B
gptkb:CAP4
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
gptkb:cancer
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:encodes
|
gptkb:caspase-8_protein
|
|
gptkbp:Entrez_Gene_ID
|
841
ENSG00000114026
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:thymus
liver
spleen
lymphoid tissue
|
|
gptkbp:fullName
|
gptkb:caspase_8
|
|
gptkbp:function
|
regulation of immune response
initiator caspase in apoptosis
involved in extrinsic apoptotic signaling pathway
|
|
gptkbp:GO_term
|
GO:0004197 (cysteine-type endopeptidase activity)
GO:0006915 (apoptotic process)
GO:0097190 (apoptotic signaling pathway)
|
|
gptkbp:HGNC_ID
|
HGNC:1509
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CASP8
|
|
gptkbp:inhibitedBy
|
gptkb:c-FLIP
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:BID
gptkb:TRADD
TNFRSF6 (Fas receptor)
|
|
gptkbp:locatedOnChromosome
|
2
2q33.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:neuroblastoma
gptkb:cancer
gptkb:autoimmune_lymphoproliferative_syndrome_type_IIB
colorectal cancer
hepatocellular carcinoma
|
|
gptkbp:OMIM
|
601763
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Casp8
gptkb:rat_Casp8
gptkb:zebrafish_casp8
|
|
gptkbp:PDB
|
gptkb:1QTN
gptkb:4JJ7
2K7Z
|
|
gptkbp:proteinFamily
|
gptkb:death_effector_domain
gptkb:caspase_domain
gptkb:caspase_family
|
|
gptkbp:UniProtID
|
gptkb:Q14790
|
|
gptkbp:bfsParent
|
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|