|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:insulin
growth factors
amino acids
nutrients
|
|
gptkbp:alsoKnownAs
|
gptkb:mammalian_target_of_rapamycin
|
|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:component
|
gptkb:mTORC1
gptkb:mTORC2
|
|
gptkbp:discoveredBy
|
gptkb:David_M._Sabatini
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:enzymeClassification
|
serine/threonine kinase
|
|
gptkbp:formsComplexWith
|
gptkb:mTORC1
gptkb:mTORC2
|
|
gptkbp:fullName
|
gptkb:mechanistic_target_of_rapamycin
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of cell motility
regulation of protein synthesis
|
|
gptkbp:gene
|
gptkb:MTOR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mTOR
|
|
gptkbp:inhibitedBy
|
gptkb:everolimus
gptkb:rapamycin
gptkb:sirolimus
gptkb:temsirolimus
gptkb:torin1
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.2
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:PDB
|
gptkb:5FLC
gptkb:6BCU
4JSV
|
|
gptkbp:phosphorylates
|
gptkb:4EBP1
gptkb:S6K1
gptkb:ULK1
gptkb:AKT
|
|
gptkbp:regulates
|
angiogenesis
lipid synthesis
immune response
cell metabolism
mitochondrial biogenesis
|
|
gptkbp:UniProtID
|
gptkb:P42345
|
|
gptkbp:bfsParent
|
gptkb:AKT_signaling_pathway
gptkb:PI3K/AKT/mTOR_pathway
gptkb:PI3K/AKT_pathway
gptkb:LY294002
gptkb:mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|