Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
stress
cytokines free radicals viral antigens bacterial antigens ultraviolet irradiation |
| gptkbp:binds |
DNA κB sites
|
| gptkbp:database |
GeneCards: NFKB1
HGNC: 7794 MeSH: D016250 UniProt: Q04206 |
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
NFKB1 gene
NFKB2 gene REL gene RELA gene RELB gene |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:fullName |
Nuclear Factor kappa-light-chain-enhancer of activated B cells
|
| gptkbp:function |
transcription factor
|
| https://www.w3.org/2000/01/rdf-schema#label |
NF-kB
|
| gptkbp:inhibitedBy |
IκB proteins
|
| gptkbp:locale |
cytoplasm (inactive)
nucleus (active) |
| gptkbp:regulates |
apoptosis
cell proliferation cell survival inflammation immune response |
| gptkbp:regulationMechanism |
IκB kinase (IKK) complex
canonical pathway non-canonical pathway proteasomal degradation of IκB |
| gptkbp:relatedTo |
gptkb:cancer
gptkb:virus asthma neurodegenerative diseases sepsis arthritis autoimmune diseases inflammatory diseases |
| gptkbp:subunit |
NF-kB1 (p50/p105)
NF-kB2 (p52/p100) RelA (p65) RelB c-Rel |
| gptkbp:bfsParent |
gptkb:AKT1
gptkb:WAF1_gene |
| gptkbp:bfsLayer |
6
|