|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CDKN2
gptkb:p33(CDK2)
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
DNA replication
G1/S transition of mitotic cell cycle
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:Entrez_Gene_ID
|
1017
ENSG00000123374
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.22
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_2
|
|
gptkbp:function
|
regulation of cell cycle
|
|
gptkbp:gene
|
gptkb:CDK2_gene
|
|
gptkbp:gene_ontology_molecular_function
|
ATP binding
protein serine/threonine kinase activity
|
|
gptkbp:HGNC_ID
|
HGNC:1771
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK2
|
|
gptkbp:inhibitedBy
|
gptkb:p21
gptkb:p27
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_A
gptkb:Cyclin_E
|
|
gptkbp:locatedOnChromosome
|
chromosome 12q13
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:mutationAssociatedWith
|
cell cycle arrest
impaired DNA replication
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Cdk2
gptkb:rat_Cdk2
|
|
gptkbp:pathway
|
p53 signaling pathway
cell cycle pathway
|
|
gptkbp:PDB
|
1FIN
|
|
gptkbp:phosphorylates
|
gptkb:RB1
gptkb:NPAT
Thr160
Tyr15
|
|
gptkbp:RefSeq
|
NM_001798
|
|
gptkbp:regulates
|
activated by cyclin binding
inhibited by phosphorylation
|
|
gptkbp:structure
|
bilobal kinase domain
|
|
gptkbp:substrate
|
gptkb:ATP
|
|
gptkbp:targetOfDrug
|
gptkb:roscovitine
gptkb:seliciclib
|
|
gptkbp:UniProtID
|
P24941
|
|
gptkbp:bfsParent
|
gptkb:umbraliciclib
gptkb:purvalanol_A
gptkb:flavopiridol
gptkb:WAF1_gene
gptkb:cyclin_A
gptkb:RB1
gptkb:p21
gptkb:p27
gptkb:roscovitine
|
|
gptkbp:bfsLayer
|
6
|