|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:metformin
gptkb:SRT1720
quercetin
resveratrol
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:type_2_diabetes
obesity
neurodegeneration
|
|
gptkbp:cofactor
|
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:Leonard_Guarente
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
gptkb:SIRT1_gene
|
|
gptkbp:Entrez_Gene_ID
|
23411
ENSG00000188976
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
adipose tissue
pancreas
|
|
gptkbp:family
|
sirtuin family
|
|
gptkbp:fullName
|
gptkb:Sirtuin_1
|
|
gptkbp:function
|
gptkb:NAD-dependent_deacetylase
DNA repair
regulation of transcription
apoptosis regulation
cellular stress response
metabolic regulation
inflammation regulation
aging regulation
|
|
gptkbp:HGNC_ID
|
HGNC:14929
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT1
|
|
gptkbp:inhibitedBy
|
nicotinamide
|
|
gptkbp:interactsWith
|
gptkb:Ku70
gptkb:SMAD7
gptkb:FOXO_transcription_factors
gptkb:E2F1
gptkb:p53
gptkb:LKB1
gptkb:NF-κB
gptkb:PGC-1α
gptkb:HIF1α
|
|
gptkbp:locatedOnChromosome
|
10q21.3
|
|
gptkbp:molecularWeight
|
82 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sirt1
|
|
gptkbp:orthologInYeast
|
gptkb:Sir2
|
|
gptkbp:PDB
|
4I5I
|
|
gptkbp:UniProtID
|
Q96EB6
|
|
gptkbp:bfsParent
|
gptkb:AMPK_pathway
|
|
gptkbp:bfsLayer
|
6
|