Properties (67)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
Protein
|
| gptkbp:agent |
gptkb:Resveratrol
|
| gptkbp:associatedWith |
metabolism
aging cancer neurodegenerative diseases metabolic syndrome obesity stress response cardiovascular diseases type 2 diabetes |
| gptkbp:culturalEvents |
SIRT2
SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 |
| gptkbp:function |
NAD+-dependent deacetylase
|
| gptkbp:geneticDiversity |
SIRT1 gene
|
| https://www.w3.org/2000/01/rdf-schema#label |
SIRT1
|
| gptkbp:interactsWith |
p53
FOXO1 NF-kB |
| gptkbp:involvedIn |
fertility
reproductive health DNA repair apoptosis cell cycle regulation immune response neurotransmitter release wound healing muscle regeneration cellular senescence cell survival muscle function oxidative stress response pain perception sleep regulation synaptic plasticity cellular differentiation extracellular matrix remodeling fatty acid oxidation neurogenesis angiogenesis neuroprotection hormonal regulation autophagy cellular communication stem cell maintenance tumor progression learning and memory bone metabolism immune evasion protein homeostasis stress adaptation inflammation regulation vascular_health cholesterol_homeostasis |
| gptkbp:is_evaluated_by |
various tissues
|
| gptkbp:isActiveIn |
SIRT1 inhibitors
|
| gptkbp:locatedIn |
yeast
|
| gptkbp:location |
nucleus
|
| gptkbp:regulates |
circadian rhythms
glucose metabolism lipid metabolism insulin sensitivity |
| gptkbp:role |
regulating gene expression
|