Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:neurodegenerative_diseases
aging obesity cardiovascular diseases longevity type 2 diabetes |
| gptkbp:community |
histone acetylation
protein acetylation |
| gptkbp:function |
NAD+-dependent deacetylase
|
| gptkbp:has_role |
cellular homeostasis
cellular metabolism chromatin remodeling metabolic disorders mitochondrial function cellular senescence oxidative stress response cellular differentiation cancer progression aging process hormonal regulation stress resistance gene silencing immune system modulation neuroprotection mechanisms protein quality control apoptotic signaling pathways |
| https://www.w3.org/2000/01/rdf-schema#label |
SIRT1
|
| gptkbp:influences |
DNA repair
insulin sensitivity fat metabolism glucose homeostasis |
| gptkbp:initiated_by |
apoptosis
NF-k B signaling PGC-1α |
| gptkbp:interacts_with |
gptkb:p53
gptkb:NF-k_B FOXO1 |
| gptkbp:involved_in |
cell cycle regulation
cellular stress response immune response tumorigenesis regulation of gene expression neuroprotection stem cell maintenance metabolic regulation cardioprotection |
| gptkbp:is_expressed_in |
gptkb:Brain
liver muscle tissue adipose tissue |
| gptkbp:is_regulated_by |
gptkb:resveratrol
gptkb:exercise caloric restriction NAD+ levels |
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promotes |
cell survival
|
| gptkbp:regulates |
metabolism
circadian rhythms inflammation |
| gptkbp:bfsParent |
gptkb:mi_R-34
gptkb:HIF1_A |
| gptkbp:bfsLayer |
6
|