|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:E2F-1
gptkb:RBBP3
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:retinoblastoma_pathway
|
|
gptkbp:biologicalProcess
|
cell proliferation
regulation of transcription
cell death
DNA binding
transcription activator activity
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Stillman
|
|
gptkbp:encodedBy
|
gptkb:E2F1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000101412
1869
|
|
gptkbp:fullName
|
gptkb:E2F_transcription_factor_1
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3113
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E2F1
|
|
gptkbp:interactsWith
|
gptkb:RB1
gptkb:Cyclin_A
gptkb:CDK2
gptkb:DP1
gptkb:HDAC1
gptkb:p53
|
|
gptkbp:locatedOnChromosome
|
gptkb:20q11.2
|
|
gptkbp:memberOf
|
gptkb:E2F_family
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:E2f1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:G1/S_transition
apoptosis
DNA replication
cell cycle
S phase entry
expression of Bcl-2 family proteins
expression of CDC6
expression of DNA polymerase alpha
expression of MCM proteins
expression of cyclin A
expression of cyclin E
expression of dihydrofolate reductase
expression of p14ARF
expression of p73
expression of ribonucleotide reductase
expression of thymidine kinase
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
gptkb:Q01094
|
|
gptkbp:bfsParent
|
gptkb:RB1
gptkb:MDM2
|
|
gptkbp:bfsLayer
|
6
|