|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCL2A
gptkb:Bcl-2_alpha
gptkb:PPP1R50
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
chronic lymphocytic leukemia
various cancers
follicular lymphoma
|
|
gptkbp:discoveredBy
|
gptkb:David_Vaux
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodes
|
gptkb:Bcl-2_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171791
596
|
|
gptkbp:fullName
|
gptkb:B-cell_lymphoma_2
|
|
gptkbp:function
|
regulation of apoptosis
anti-apoptotic protein
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:990
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BCL2
|
|
gptkbp:interactsWith
|
gptkb:BAD
gptkb:MCL1
gptkb:BID
gptkb:BAX
gptkb:BCL2L1
gptkb:BCL2A1
gptkb:BCL2L11
gptkb:BCL2L2
|
|
gptkbp:length
|
239 amino acids
approx. 23 kb
|
|
gptkbp:locatedOnChromosome
|
18q21.33
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:numberOfExons
|
3
|
|
gptkbp:OMIM
|
151430
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Bcl2
|
|
gptkbp:orthologInZebrafish
|
bcl2a
|
|
gptkbp:PDB
|
gptkb:1G5M
gptkb:4MAN
2O2F
|
|
gptkbp:proteinFamily
|
gptkb:Bcl-2_family
|
|
gptkbp:regulates
|
gptkb:p53
phosphorylation
cell death
microRNAs
mitochondrial membrane permeability
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
nuclear envelope
mitochondrial outer membrane
|
|
gptkbp:target
|
gptkb:oblimersen
gptkb:venetoclax
|
|
gptkbp:tissue_specificity
|
various tissues
lymphoid tissue
|
|
gptkbp:translocationAssociatedWith
|
follicular lymphoma
|
|
gptkbp:translocationPartner
|
gptkb:t(14;18)(q32;q21)
|
|
gptkbp:UniProtID
|
P10415
|
|
gptkbp:bfsParent
|
gptkb:AKT1
gptkb:Beclin-1
gptkb:chromosome_18
gptkb:EGR1
gptkb:BAX
gptkb:p53
|
|
gptkbp:bfsLayer
|
6
|