Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
apoptosis |
| gptkbp:code |
gptkb:B-cell_lymphoma_2_protein
|
| gptkbp:contribution |
autoimmune diseases
|
| gptkbp:discovered_by |
gptkb:1980s
|
| gptkbp:function |
regulates cell death
|
| gptkbp:genetic_studies |
can lead to malignancies
linked to follicular lymphoma |
| gptkbp:has_role |
cellular stress response
immune response tumorigenesis |
| https://www.w3.org/2000/01/rdf-schema#label |
BCL2
|
| gptkbp:influences |
chemoresistance
|
| gptkbp:initiated_by |
caspase activation
|
| gptkbp:interacts_with |
BAX
|
| gptkbp:involved_in |
gptkb:Oncology
gptkb:neurodegenerative_diseases |
| gptkbp:is_associated_with |
chronic diseases
tumor microenvironment cellular aging poor prognosis |
| gptkbp:is_expressed_at |
high levels in tumors
|
| gptkbp:is_expressed_in |
various tissues
B cells various cancers hematopoietic cells |
| gptkbp:is_involved_in |
cell cycle regulation
cellular homeostasis cellular differentiation neuroprotection cellular signaling cellular repair mechanisms cellular adaptation metabolic regulation immune evasion |
| gptkbp:is_linked_to |
inflammation
metastasis therapeutic resistance drug resistance |
| gptkbp:is_located_in |
gptkb:Atom
|
| gptkbp:is_part_of |
cancer progression
Bcl-2 family of proteins anti-apoptotic pathway |
| gptkbp:is_regulated_by |
transcription factors
external stressors micro RNAs |
| gptkbp:is_targeted_at |
therapeutic agents
cancer therapies novel drugs BH3 mimetics |
| gptkbp:located_in |
chromosome 18
|
| gptkbp:overexpression |
promotes cell survival
|
| gptkbp:promotes |
tumor cell survival
|
| gptkbp:regulates |
apoptotic signaling pathways
mitochondrial membrane permeability |
| gptkbp:transcriptionally_activated_by |
gptkb:NF-k_B
|
| gptkbp:transcriptionally_repressed_by |
gptkb:p53
|
| gptkbp:bfsParent |
gptkb:mi_R-145
|
| gptkbp:bfsLayer |
7
|