|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:p53
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tumor protein p53
|
|
gptkbp:interactsWith
|
gptkb:CHEK2
gptkb:ARF
gptkb:CBP/p300
gptkb:BAX
gptkb:GADD45
gptkb:p21
gptkb:MDM2
gptkb:BRCA1
gptkb:E2F1
gptkb:14-3-3σ
ATM
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
~53 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:PDB
|
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
DNA repair
angiogenesis
cell cycle
senescence
negatively regulated by MDM2
|
|
gptkbp:role
|
gptkb:Li-Fraumeni_syndrome
development
aging
fertility
metabolism
immune response
autophagy
cellular stress response
response to oxidative stress
genomic stability
response to hypoxia
response to DNA damage
stem cell regulation
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:TP53
|
|
gptkbp:bfsLayer
|
6
|