Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:can_lead_to |
tumor development when mutated
|
| gptkbp:code |
gptkb:TP53_gene
|
| gptkbp:discovered_by |
gptkb:David_Lane
|
| gptkbp:diseases |
gptkb:Oncology
|
| gptkbp:function |
tumor suppression
|
| gptkbp:genetic_studies |
loss of function
over 50% of human cancers |
| gptkbp:has_a_focus_on |
gene therapy research
molecular biology research cancer genetics research |
| gptkbp:has_role |
senescence
|
| https://www.w3.org/2000/01/rdf-schema#label |
tumor protein p53
|
| gptkbp:initiated_by |
gptkb:MDM2
cell proliferation p21 DNA damage BAX |
| gptkbp:interacts_with |
gptkb:MDM2
p300 |
| gptkbp:involved_in |
cell cycle regulation
|
| gptkbp:is_a_key_regulator_of |
cellular stress responses
|
| gptkbp:is_a_member_of |
p53 family
|
| gptkbp:is_a_subject_of |
clinical trials
|
| gptkbp:is_associated_with |
tumorigenesis
genomic stability metastasis chemoresistance |
| gptkbp:is_expressed_in |
most tissues
|
| gptkbp:is_involved_in |
DNA repair
apoptosis cellular homeostasis immune response cellular differentiation cellular signaling pathways metabolism regulation cellular repair mechanisms cellular apoptosis pathways |
| gptkbp:is_known_to |
respond to stress signals
|
| gptkbp:is_linked_to |
gptkb:Li-Fraumeni_syndrome
tumor progression apoptotic pathways radiation response |
| gptkbp:is_part_of |
p53 pathway
|
| gptkbp:is_regulated_by |
ubiquitination
cellular responses to stress. |
| gptkbp:is_studied_for |
therapeutic interventions
biomarker potential |
| gptkbp:is_studied_in |
oncology
|
| gptkbp:key_player |
cancer prevention
|
| gptkbp:known_as |
guardian of the genome
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:participated_in |
cell cycle arrest
|
| gptkbp:promoter |
gptkb:TP53
|
| gptkbp:role |
DNA binding
|
| gptkbp:targets |
gptkb:immunotherapy
cancer therapy small molecule drugs |
| gptkbp:type_of |
gptkb:DNA
|
| gptkbp:was_a_factor_in |
tumor microenvironment
|
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
5
|