|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:biologicalProcess
|
gptkb:Wnt_signaling_pathway
cell differentiation
ATP binding
apoptotic process
glycogen metabolic process
protein serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Dale_E._Krebs
gptkb:Edwin_G._Krebs
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:encodedBy
|
gptkb:GSK3A
gptkb:GSK3B
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.26
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase_3
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of Wnt signaling pathway
regulation of circadian rhythm
regulation of glycogen synthesis
regulation of insulin signaling
|
|
gptkbp:hasIsoform
|
gptkb:GSK3α
gptkb:GSK3β
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK3
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:Tideglusib
gptkb:CHIR99021
lithium
|
|
gptkbp:locatedOnChromosome
|
gptkb:19q13.2_(GSK3A)
gptkb:3q13.33_(GSK3B)
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:otherName
|
gptkb:GSK-3
gptkb:GSK-3α
gptkb:GSK-3β
|
|
gptkbp:phosphorylates
|
gptkb:cyclin_D1
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:c-Myc
gptkb:β-catenin
|
|
gptkbp:proteinFamily
|
serine/threonine protein kinase
|
|
gptkbp:regulates
|
activated by tyrosine phosphorylation
inhibited by phosphorylation at Ser21 (GSK3α)
inhibited by phosphorylation at Ser9 (GSK3β)
|
|
gptkbp:UniProtID
|
gptkb:P49840
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:bfsLayer
|
5
|