Li-Fraumeni syndrome

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instance_of gptkb:Genetics
gptkbp:advocacy patient education
awareness campaigns
fundraising for research
gptkbp:affects individuals and families
gptkbp:associated_with TP53 gene mutations
gptkbp:cause increased risk of cancer
gptkbp:characterized_by early onset of various cancers
gptkbp:common_cancers gptkb:adrenal_cortical_carcinoma
gptkb:Oncology
brain tumors
sarcomas
gptkbp:condition gptkb:Cowden_syndrome
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
gptkbp:diagnosis genetic testing
clinical criteria
gptkbp:discovery Frederick Li and Joseph Fraumeni
gptkbp:first_described_by gptkb:1969
gptkbp:future_prospects monitoring required
lifetime cancer risk
gptkbp:genetic_counseling_importance risk assessment
psychological support
family planning
https://www.w3.org/2000/01/rdf-schema#label Li-Fraumeni syndrome
gptkbp:impact_on_life_expectancy variable
gptkbp:inherits_from autosomal dominant
gptkbp:is_involved_in gptkb:Li-Fraumeni_Syndrome_Association
cancer support networks
gptkbp:notable_case notable individuals with the syndrome
gptkbp:prevalence rare
gptkbp:research_focus cancer genetics
TP53 gene function
gptkbp:risk_factor family history
genetic predisposition
gptkbp:screenings genetic counseling
clinical breast exams
annual MRI scans
gptkbp:symptoms multiple primary cancers
early cancer diagnosis
gptkbp:treatment surveillance
radiation therapy
chemotherapy
preventive surgery
gptkbp:bfsParent gptkb:TP53_mutation
gptkb:primary_glioblastoma
gptkb:secondary_glioblastoma
gptkb:TP53
gptkbp:bfsLayer 5