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gptkbp:instance_of
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gptkb:physicist
|
|
gptkbp:bfsLayer
|
4
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|
gptkbp:bfsParent
|
gptkb:primary_glioblastoma
gptkb:secondary_glioblastoma
gptkb:alveolar_rhabdomyosarcoma
gptkb:p53_gene
|
|
gptkbp:advocates_for
|
patient education
awareness campaigns
fundraising for research
|
|
gptkbp:affects
|
individuals and families
|
|
gptkbp:associated_with
|
T P53 gene mutations
|
|
gptkbp:caused_by
|
increased risk of cancer
|
|
gptkbp:common_name
|
gptkb:healthcare_organization
gptkb:adrenal_cortical_carcinoma
brain tumors
sarcomas
|
|
gptkbp:counseling_services
|
risk assessment
psychological support
family planning
|
|
gptkbp:current_use
|
gptkb:Cowden_syndrome
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
|
|
gptkbp:descendant
|
autosomal dominant
|
|
gptkbp:discovered_by
|
Frederick Li and Joseph Fraumeni
|
|
gptkbp:first_described_by
|
gptkb:1969
|
|
gptkbp:future_plans
|
monitoring required
lifetime cancer risk
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Li-Fraumeni syndrome
|
|
gptkbp:is_characterized_by
|
early onset of various cancers
|
|
gptkbp:is_involved_in
|
gptkb:Li-Fraumeni_Syndrome_Association
cancer support networks
|
|
gptkbp:is_popular_in
|
rare
|
|
gptkbp:lifespan
|
variable
|
|
gptkbp:notable_event
|
notable individuals with the syndrome
|
|
gptkbp:research_focus
|
cancer genetics
T P53 gene function
|
|
gptkbp:risk_factor
|
family history
genetic predisposition
|
|
gptkbp:screenings
|
genetic counseling
clinical breast exams
annual MRI scans
|
|
gptkbp:social_responsibility
|
genetic testing
clinical criteria
|
|
gptkbp:symptoms
|
multiple primary cancers
early cancer diagnosis
|
|
gptkbp:treatment
|
surveillance
radiation therapy
chemotherapy
preventive surgery
|