gptkbp:instance_of
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gptkb:Genetics
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gptkbp:advocacy
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patient education
awareness campaigns
fundraising for research
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gptkbp:affects
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individuals and families
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gptkbp:associated_with
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TP53 gene mutations
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gptkbp:cause
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increased risk of cancer
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gptkbp:characterized_by
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early onset of various cancers
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gptkbp:common_cancers
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gptkb:adrenal_cortical_carcinoma
gptkb:Oncology
brain tumors
sarcomas
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gptkbp:condition
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gptkb:Cowden_syndrome
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
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gptkbp:diagnosis
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genetic testing
clinical criteria
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gptkbp:discovery
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Frederick Li and Joseph Fraumeni
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gptkbp:first_described_by
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gptkb:1969
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gptkbp:future_prospects
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monitoring required
lifetime cancer risk
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gptkbp:genetic_counseling_importance
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risk assessment
psychological support
family planning
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https://www.w3.org/2000/01/rdf-schema#label
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Li-Fraumeni syndrome
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gptkbp:impact_on_life_expectancy
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variable
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gptkbp:inherits_from
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autosomal dominant
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gptkbp:is_involved_in
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gptkb:Li-Fraumeni_Syndrome_Association
cancer support networks
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gptkbp:notable_case
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notable individuals with the syndrome
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gptkbp:prevalence
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rare
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gptkbp:research_focus
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cancer genetics
TP53 gene function
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gptkbp:risk_factor
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family history
genetic predisposition
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gptkbp:screenings
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genetic counseling
clinical breast exams
annual MRI scans
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gptkbp:symptoms
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multiple primary cancers
early cancer diagnosis
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gptkbp:treatment
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surveillance
radiation therapy
chemotherapy
preventive surgery
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gptkbp:bfsParent
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gptkb:TP53_mutation
gptkb:primary_glioblastoma
gptkb:secondary_glioblastoma
gptkb:TP53
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gptkbp:bfsLayer
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5
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