Statements (70)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Cyclin-dependent_kinase
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:discovered_by |
1990s
|
| gptkbp:form |
JNK1
JNK2 JNK3 |
| gptkbp:function |
regulates cellular responses to stress
|
| https://www.w3.org/2000/01/rdf-schema#label |
JNK
|
| gptkbp:initiated_by |
stress signals
certain phosphatases |
| gptkbp:interacts_with |
gptkb:c-Jun
ATF2 |
| gptkbp:involved_in |
gptkb:embryonic_development
gptkb:addiction fertility reproductive health DNA damage response aging apoptosis cell cycle regulation cell proliferation cellular homeostasis immune response signal transduction autoimmune diseases chronic pain inflammation metabolic syndrome wound healing neuroinflammation fibrosis cellular senescence neuronal signaling oxidative stress response synaptic plasticity cellular differentiation muscle atrophy neurogenesis atherosclerosis tissue repair viral infections neuroprotection cell migration metastasis hormonal regulation psychiatric disorders bacterial infections neurodevelopmental disorders tumor progression learning and memory behavioral responses metabolic regulation hypoxia response cytokine signaling stem cell differentiation circadian rhythm regulation placental function stress-induced signaling chronic stress response endoplasmic reticulum stress |
| gptkbp:is_expressed_in |
various tissues
|
| gptkbp:is_studied_in |
gptkb:diabetes
gptkb:neurodegenerative_diseases cardiovascular diseases |
| gptkbp:known_as |
c-Jun N-terminal kinase
|
| gptkbp:part_of |
MAPK signaling pathway
|
| gptkbp:regulates |
gene expression
|
| gptkbp:targets |
drug development
|
| gptkbp:bfsParent |
gptkb:SPDR_Bloomberg_Barclays_High_Yield_Bond_ETF
|
| gptkbp:bfsLayer |
7
|