|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:AMP
gptkb:ADP
|
|
gptkbp:composedOf
|
alpha subunit
beta subunit
gamma subunit
|
|
gptkbp:discoveredBy
|
gptkb:D._Grahame_Hardie
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:fullName
|
gptkb:AMP-activated_protein_kinase
|
|
gptkbp:function
|
cellular energy sensor
|
|
gptkbp:gene
|
gptkb:PRKAA1
gptkb:PRKAA2
gptkb:PRKAB1
gptkb:PRKAB2
gptkb:PRKAG1
gptkb:PRKAG2
gptkb:PRKAG3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AMPK
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
gptkb:mTOR_pathway
fatty acid synthesis
|
|
gptkbp:involvedIn
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
autophagy
cellular stress response
exercise response
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:phosphorylates
|
gptkb:HMG-CoA_reductase
gptkb:acetyl-CoA_carboxylase
|
|
gptkbp:promotion
|
glucose uptake
fatty acid oxidation
|
|
gptkbp:regulates
|
lipid metabolism
metabolism
cell growth
protein synthesis
appetite
glucose metabolism
inflammation
cell cycle
cell polarity
insulin sensitivity
mitochondrial biogenesis
oxidative stress
|
|
gptkbp:target
|
gptkb:AICAR
gptkb:metformin
gptkb:thiazolidinediones
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT_pathway
gptkb:mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|