|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:phosphoinositide_3-kinase_(PI3K)_pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:Protein_kinase_B
|
|
gptkbp:discoveredBy
|
gptkb:Staal_et_al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of cell growth
regulation of cell migration
regulation of metabolism
serine/threonine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT
|
|
gptkbp:inhibitedBy
|
gptkb:AZD5363
gptkb:Ipatasertib
gptkb:MK-2206
gptkb:Perifosine
|
|
gptkbp:involvedIn
|
gptkb:cancer
gptkb:diabetes
apoptosis regulation
insulin signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:14q32.33_(AKT1)
gptkb:19q13.1_(AKT2)
gptkb:1q44_(AKT3)
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT/mTOR_pathway
|
|
gptkbp:phosphorylates
|
gptkb:GSK-3
gptkb:TSC2
gptkb:BAD
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR
|
|
gptkbp:proteinFamily
|
gptkb:AKT_family
|
|
gptkbp:regulates
|
angiogenesis
glucose uptake
protein synthesis
cell cycle
autophagy
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:UniProtID
|
gptkb:P31749
P31751
Q9Y243
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT/mTOR_pathway
gptkb:PI3K/AKT_pathway
gptkb:mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|