|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
cleavage by initiator caspases
|
|
gptkbp:alias
|
gptkb:Yama
gptkb:CPP32
SCA-1
apopain
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
apoptotic process
proteolysis
cysteine-type endopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
cytosol
|
|
gptkbp:discoveredBy
|
Yuan et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:Entrez_Gene_ID
|
836
ENSG00000164305
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.4.22.56
|
|
gptkbp:fullName
|
gptkb:Caspase-3
|
|
gptkbp:function
|
execution-phase apoptosis protease
|
|
gptkbp:gene
|
gptkb:CASP3
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
GO:0006915
GO:0004197
|
|
gptkbp:hasIsoform
|
2
|
|
gptkbp:HGNC_ID
|
HGNC:1504
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CASP3
|
|
gptkbp:inhibitedBy
|
gptkb:XIAP
BIRC5
|
|
gptkbp:locatedOnChromosome
|
4
4q34
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:OMIM
|
600636
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Casp3
|
|
gptkbp:pathway
|
apoptosis pathway
caspase cascade
|
|
gptkbp:PDB
|
gptkb:1PAU
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:caspase_family
|
|
gptkbp:structure
|
heterotetramer (2 large and 2 small subunits)
|
|
gptkbp:substrate
|
gptkb:ICAD
poly(ADP-ribose) polymerase (PARP)
|
|
gptkbp:substrateRecognitionSequence
|
DEVD
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P42574
|
|
gptkbp:bfsParent
|
gptkb:P49918
|
|
gptkbp:bfsLayer
|
7
|