|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:cyclin-dependent_kinase_inhibitor_1
gptkb:p21
gptkb:CIP1
gptkb:WAF1
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
Xiong et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:CDKN1A_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000124762
1026
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
cell cycle regulation
inhibits cyclin-dependent kinases
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1784
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN1A (p21)
|
|
gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
|
|
gptkbp:interactsWith
|
gptkb:GADD45
gptkb:p53
gptkb:PCNA
CDK2-cyclin E complex
CDK4-cyclin D complex
|
|
gptkbp:involvedIn
|
apoptosis
cellular senescence
DNA damage response
tumor suppression
|
|
gptkbp:length
|
164
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
gptkb:6p21.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
premature aging
|
|
gptkbp:OMIM
|
116899
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1a
|
|
gptkbp:phosphorylates
|
gptkb:AKT
gptkb:CDK2
PKA
|
|
gptkbp:proteinFamily
|
gptkb:CIP/KIP_family
|
|
gptkbp:regulates
|
gptkb:p53
cell proliferation
G1 phase of cell cycle
S phase of cell cycle
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:Tp53
|
|
gptkbp:bfsLayer
|
7
|