|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCC7
gptkb:LFS1
P53
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodes
|
gptkb:tumor_protein_p53
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TP53
|
|
gptkbp:involvedIn
|
aging
immune response
autophagy
cellular stress response
metabolism regulation
oncogenesis
angiogenesis inhibition
response to DNA damage
stem cell regulation
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:mostMutatedGeneIn
|
human cancer
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Li-Fraumeni_syndrome
nonsense
deletion
missense
splicing
various cancers
frameshift
|
|
gptkbp:mutationFrequencyInCancer
|
high
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trp53
gptkb:Tp53
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:product
|
gptkb:p53
|
|
gptkbp:proteinFamily
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:USP7
gptkb:FAS
gptkb:ARF
gptkb:BAX
gptkb:GADD45
gptkb:NOXA
gptkb:PUMA
gptkb:MDM2
gptkb:CHK2
gptkb:BCL2_family_proteins
gptkb:E6_(HPV_protein)
gptkb:WIP1
gptkb:p21_(CDKN1A)
apoptosis
ATM
DNA repair
cell cycle
senescence
genomic stability
|
|
gptkbp:significance
|
target for cancer therapy
biomarker for cancer prognosis
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:clear_cell_ovarian_carcinoma
gptkb:Squamous_Cell_Carcinoma_of_the_Lung
|
|
gptkbp:bfsLayer
|
5
|