Statements (125)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:Li-Fraumeni_syndrome poor prognosis treatment resistance |
| gptkbp:code |
gptkb:tumor_protein_p53
|
| gptkbp:discovered_by |
gptkb:David_Lane
|
| gptkbp:expression_regulated_by |
hypoxia
oncogenes DNA damage tumor suppressors |
| gptkbp:function |
tumor suppression
|
| gptkbp:genetic_studies |
high in tumors
loss of function tumor heterogeneity altered metabolism metastasis frameshift mutation increased oxidative stress immune evasion missense mutation increased angiogenesis altered protein function nonsense mutation gain of function common in human tumors altered cell adhesion altered cell signaling altered differentiation altered extracellular matrix interactions enhanced cell survival increased genomic instability increased inflammation increased tumorigenesis resistance to apoptosis more than 50% of human tumors |
| gptkbp:has_role |
DNA repair
genomic stability |
| gptkbp:has_variants |
gptkb:TP53_G245_S
gptkb:TP53_R175_H gptkb:TP53_R273_H E285 K G245 S R175 H R248 Q R273 H del(17p) |
| https://www.w3.org/2000/01/rdf-schema#label |
TP53
|
| gptkbp:initiated_by |
cell proliferation
p21 DNA repair genes |
| gptkbp:interacts_with |
gptkb:MDM2
gptkb:CHEK2 gptkb:p53_R2 ATM p300 CBP |
| gptkbp:involved_in |
apoptosis
cellular stress response immune response cellular senescence genomic stability metabolic regulation apoptotic signaling pathway |
| gptkbp:is_associated_with |
gptkb:Oncology
gptkb:Li-Fraumeni_syndrome |
| gptkbp:is_common_in |
gptkb:Oncology
|
| gptkbp:is_essential_for |
cellular response to stress
|
| gptkbp:is_expressed_in |
most tissues
|
| gptkbp:is_involved_in |
DNA damage response
cellular homeostasis immune response cellular senescence tumor suppression oxidative stress response tumor microenvironment cellular aging cellular differentiation angiogenesis metastasis cellular signaling pathways cellular signaling metabolism regulation cellular repair mechanisms cellular differentiation pathways cellular repair pathways cellular growth regulation cellular apoptosis pathways cellular stress response pathways cellular survival pathways cellular proliferation pathways cellular metabolism pathways cellular apoptosis regulation cellular differentiation regulation pathways cellular growth regulation pathways cellular metabolism regulation pathways cellular proliferation regulation cellular stress regulation cellular survival regulation pathways |
| gptkbp:is_part_of |
p53 pathway
|
| gptkbp:is_recognized_as |
gptkb:1979
|
| gptkbp:is_regulated_by |
gptkb:CHK2
gptkb:MDM2 gptkb:ATR ATM ARF p14 ARF |
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
gptkb:gene_therapy
gptkb:CRISPR_technology small molecules |
| gptkbp:known_as |
gptkb:p53
|
| gptkbp:located_in |
chromosome 17
|
| gptkbp:orthologs |
other species
|
| gptkbp:promoter |
p53 family
|
| gptkbp:regulates |
cell cycle
cellular response to stress |
| gptkbp:role |
DNA repair
apoptosis cell cycle regulation |
| gptkbp:targets |
gptkb:cancer_treatment
cancer therapies |
| gptkbp:bfsParent |
gptkb:Oncology
gptkb:pancreatic_cancer |
| gptkbp:bfsLayer |
4
|