Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:code |
gptkb:MDM2_protein
|
| gptkbp:function |
regulates p53
|
| gptkbp:genetic_studies |
certain cancers
|
| gptkbp:has_role |
DNA damage response
|
| gptkbp:has_variants |
SNPs
|
| https://www.w3.org/2000/01/rdf-schema#label |
MDM2
|
| gptkbp:initiated_by |
gptkb:nutlin-3
apoptosis |
| gptkbp:interacts_with |
gptkb:p53
|
| gptkbp:involved_in |
tumorigenesis
|
| gptkbp:is_associated_with |
tumor microenvironment
poor prognosis chemoresistance viral oncogenesis |
| gptkbp:is_expressed_in |
gptkb:Oncology
gptkb:Kaposi's_sarcoma gptkb:pancreatic_cancer gptkb:neuroblastoma ovarian cancer various tissues embryogenesis esophageal cancer bladder cancer head and neck cancer |
| gptkbp:is_involved_in |
cell cycle regulation
cellular homeostasis cellular stress response DNA repair mechanisms cellular senescence cellular differentiation cellular signaling pathways metabolic regulation cellular repair processes cellular apoptosis |
| gptkbp:is_linked_to |
chronic inflammation
epigenetic modifications metastasis therapeutic resistance immune evasion |
| gptkbp:is_part_of |
tumor suppressor network
p53 pathway |
| gptkbp:is_regulated_by |
gptkb:mi_R-34
ubiquitination |
| gptkbp:is_studied_for |
therapeutic interventions
biomarker potential |
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
gptkb:gene_therapy
gptkb:immunotherapy gptkb:CRISPR_technology |
| gptkbp:located_in |
chromosome 12
|
| gptkbp:orthologs |
MDM4
|
| gptkbp:overexpressed_in |
tumors
|
| gptkbp:promotes |
cell proliferation
|
| gptkbp:targets |
small molecule inhibitors
|
| gptkbp:type |
gptkb:Oni
|
| gptkbp:bfsParent |
gptkb:Oncology
|
| gptkbp:bfsLayer |
4
|