|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:E3_ubiquitin-protein_ligase_Mdm2
Double minute 2 protein
HDMX-interacting protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_J._Levine
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:E3_ubiquitin-protein_ligase_Mdm2
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135679
4193
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
E3 ubiquitin ligase
negative regulator of p53
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6973
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MDM2
|
|
gptkbp:inhibitedBy
|
gptkb:p53
|
|
gptkbp:interactsWith
|
gptkb:MDMX
gptkb:RPL11
gptkb:RPL5
gptkb:p14ARF
gptkb:p63
gptkb:p73
gptkb:ARF
gptkb:E2F1
gptkb:p53
ribosomal proteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
leukemia
liposarcoma
|
|
gptkbp:OMIM
|
164785
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mdm2
|
|
gptkbp:phosphorylates
|
gptkb:ATM_kinase
gptkb:AKT
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:p53
|
|
gptkbp:target
|
gptkb:RG7112
gptkb:idasanutlin
gptkb:nutlin-3
|
|
gptkbp:UniProtID
|
gptkb:Q00987
|
|
gptkbp:bfsParent
|
gptkb:AKT_signaling_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:bfsLayer
|
5
|