|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PLK
STPK13
Serine/threonine-protein kinase PLK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
|
|
gptkbp:biologicalProcess
|
DNA damage response
cytokinesis
mitotic entry
spindle assembly
|
|
gptkbp:discoveredBy
|
gptkb:David_Glover
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:Entrez_Gene_ID
|
5347
ENSG00000166851
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.21
|
|
gptkbp:expressedIn
|
high in proliferating cells
upregulated in tumors
|
|
gptkbp:fullName
|
Polo-like kinase 1
|
|
gptkbp:function
|
cell cycle progression
serine/threonine-protein kinase
regulation of mitosis
|
|
gptkbp:gene
|
gptkb:PLK1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:9077
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLK1
|
|
gptkbp:inhibitedBy
|
BI 2536
GSK461364
volasertib
|
|
gptkbp:locatedOnChromosome
|
16
|
|
gptkbp:location
|
gptkb:16p12.2
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila polo
mouse Plk1
|
|
gptkbp:pathway
|
cell cycle
DNA damage checkpoint
mitotic spindle checkpoint
|
|
gptkbp:PDB
|
4J7B
|
|
gptkbp:phosphorylates
|
gptkb:CDC25C
gptkb:BUB1
gptkb:NPM1
WEE1
|
|
gptkbp:regulates
|
activated by phosphorylation
degraded by APC/C
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
kinetochore
centrosome
spindle pole
|
|
gptkbp:UniProtID
|
P53350
|
|
gptkbp:bfsParent
|
gptkb:PLK
gptkb:CDC25C
gptkb:Cyclin_B1
gptkb:BubR1
gptkb:Plk
gptkb:MiR100
|
|
gptkbp:bfsLayer
|
7
|