|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:interleukin-6
growth factors
phosphorylation
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Darnell
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:STAT3_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000168610
6774
|
|
gptkbp:fullName
|
gptkb:Signal_transducer_and_activator_of_transcription_3
|
|
gptkbp:function
|
signal transduction
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11364
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT3
|
|
gptkbp:inhibitedBy
|
gptkb:S3I-201
gptkb:Stattic
gptkb:WP1066
|
|
gptkbp:interactsWith
|
gptkb:JAK2
gptkb:EGFR
gptkb:SOCS3
gptkb:PIAS3
gptkb:SRC
gptkb:JAK1
gptkb:GRB2
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
cytokine signaling
|
|
gptkbp:locatedOnChromosome
|
17q21.31
|
|
gptkbp:molecularWeight
|
88 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Hyper-IgE_syndrome
cancers
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1BG1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P40763
|
|
gptkbp:bfsParent
|
gptkb:P42336
gptkb:c-Met
gptkb:PDGFRB
gptkb:FGFR1
|
|
gptkbp:bfsLayer
|
6
|