Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
JAKs
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:code |
STAT3 gene
|
| gptkbp:dimerizes_with |
STAT1
STAT5 |
| gptkbp:function |
gptkb:DNA
|
| gptkbp:has_role |
gptkb:Oni
|
| https://www.w3.org/2000/01/rdf-schema#label |
STAT3
|
| gptkbp:initiated_by |
apoptosis
phosphorylation cytokines SOCS proteins |
| gptkbp:interacts_with |
gptkb:JAK1
gptkb:IL-6 EGF JAK2 |
| gptkbp:involved_in |
apoptosis regulation
cell growth immune response cytokine signaling |
| gptkbp:is_associated_with |
chronic inflammation
|
| gptkbp:is_expressed_in |
various tissues
|
| gptkbp:is_involved_in |
gptkb:neurodegenerative_diseases
cell differentiation cellular homeostasis cellular metabolism cellular stress response developmental processes chronic diseases wound healing neuroinflammation fibrosis tumor microenvironment cellular responses to stimuli angiogenesis inflammatory response tissue repair viral infections metastasis cellular signaling pathways bacterial infections cellular communication stem cell maintenance cellular signaling cellular adaptation metabolic regulation immune evasion hormonal signaling response to stress |
| gptkbp:is_linked_to |
autoimmune diseases
cardiovascular diseases |
| gptkbp:is_part_of |
signal transduction pathway
|
| gptkbp:is_regulated_by |
suppressors
|
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
STAT3 inhibitors
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:promotes |
cell proliferation
|
| gptkbp:regulates |
gene expression
|
| gptkbp:weight |
approximately 85 k Da
|
| gptkbp:bfsParent |
gptkb:EGFR
|
| gptkbp:bfsLayer |
5
|