Statements (71)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
gptkb:p53
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:Li-Fraumeni_syndrome |
| gptkbp:code |
gptkb:CHEK2_gene
|
| gptkbp:function |
DNA damage response
|
| gptkbp:genetic_studies |
certain cancers
|
| gptkbp:has_role |
tumor suppression
|
| https://www.w3.org/2000/01/rdf-schema#label |
CHK2
|
| gptkbp:initiated_by |
gptkb:ATM_kinase
gptkb:Mdm2 DNA double-strand breaks cell proliferation cell cycle checkpoints |
| gptkbp:interacts_with |
gptkb:TP53
|
| gptkbp:involved_in |
cell cycle regulation
|
| gptkbp:is_associated_with |
genetic predisposition to cancer
tumor suppressor functions |
| gptkbp:is_essential_for |
DNA repair mechanisms
|
| gptkbp:is_expressed_in |
various tissues
cellular response to DNA damage |
| gptkbp:is_involved_in |
cellular homeostasis
cellular metabolism cellular response to stress cellular differentiation genomic stability cellular signaling pathways cellular growth regulation cellular repair processes cellular response to bacterial infection cellular response to cytokines cellular response to hypoxia cellular response to mechanical stress cellular response to viral infection cellular apoptosis pathways cellular response to growth factors cellular response to metabolic stress cellular response to nutrient deprivation cellular response to environmental stressors cellular response to chemical stress cellular response to heat shock cellular response to hormonal signals cellular response to immune signals cellular proliferation control DNA repair signaling cellular repair of DNA damage cellular response to DNA damage signals cellular response to chemokines cellular response to genotoxic stress cellular response to neurotransmitters cellular response to signaling molecules cellular response to stress hormones checkpoint signaling pathways response to UV radiation response to ionizing radiation response to oxidative stress |
| gptkbp:is_linked_to |
cellular senescence
tumorigenesis |
| gptkbp:is_part_of |
signal transduction pathways
DNA repair pathways checkpoint kinase family |
| gptkbp:is_regulated_by |
post-translational modifications
cellular stress signals |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
small molecule inhibitors
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:promoter |
gptkb:CHEK2
|
| gptkbp:regulates |
apoptosis
|
| gptkbp:weight |
approximately 80 k Da
|
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
5
|