|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:ATM_kinase
|
|
gptkbp:alternativeName
|
gptkb:CHEK2
Checkpoint kinase 2
Rad53 homolog
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
CHEK2 gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:fullName
|
Checkpoint kinase 2
|
|
gptkbp:function
|
serine/threonine-protein kinase
DNA damage checkpoint control
|
|
gptkbp:involvedIn
|
apoptosis
DNA repair
cell cycle arrest
|
|
gptkbp:locatedOnChromosome
|
22q12.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_breast_cancer
gptkb:Li-Fraumeni_syndrome
prostate cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
Saccharomyces cerevisiae (Rad53)
|
|
gptkbp:phosphorylates
|
gptkb:CDC25C
gptkb:BRCA1
gptkb:p53
|
|
gptkbp:regulates
|
cell cycle progression
DNA damage response
|
|
gptkbp:structure
|
contains kinase domain
contains FHA domain
|
|
gptkbp:UniProtID
|
O96017
|
|
gptkbp:bfsParent
|
gptkb:ATM_kinase
gptkb:MDMX
gptkb:TP53
gptkb:KDM4B
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHK2
|