Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:activatedBy |
gptkb:ATM_kinase
|
| gptkbp:alternativeName |
gptkb:CHEK2
Checkpoint kinase 2 Rad53 homolog |
| gptkbp:discoveredIn |
1999
|
| gptkbp:encodedBy |
CHEK2 gene
|
| gptkbp:enzymeCommissionNumber |
2.7.11.1
|
| gptkbp:fullName |
Checkpoint kinase 2
|
| gptkbp:function |
serine/threonine-protein kinase
DNA damage checkpoint control |
| https://www.w3.org/2000/01/rdf-schema#label |
CHK2
|
| gptkbp:involvedIn |
apoptosis
DNA repair cell cycle arrest |
| gptkbp:locatedOnChromosome |
22q12.1
|
| gptkbp:mutationAssociatedWith |
gptkb:hereditary_breast_cancer
gptkb:Li-Fraumeni_syndrome prostate cancer |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
Saccharomyces cerevisiae (Rad53) |
| gptkbp:phosphorylates |
gptkb:CDC25C
gptkb:BRCA1 gptkb:p53 |
| gptkbp:regulates |
cell cycle progression
DNA damage response |
| gptkbp:structure |
contains kinase domain
contains FHA domain |
| gptkbp:UniProtID |
O96017
|
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
6
|