RAF1 gene

URI: https://gptkb.org/entity/RAF1_gene

GPTKB entity

Statements (96)

Predicate	Object
gptkbp:instanceOf	gptkb:gene
gptkbp:alternativeName	gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase gptkb:c-RAF
gptkbp:associatedWith	gptkb:LEOPARD_syndrome gptkb:cancer gptkb:Noonan_syndrome
gptkbp:discoveredBy	Ullrich et al.
gptkbp:discoveredIn	1985
gptkbp:encodes	gptkb:RAF1_protein
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000132155 5894
gptkbp:expressedIn	various tissues
gptkbp:function	encodes a serine/threonine-protein kinase
gptkbp:HGNC_ID	9829
https://www.w3.org/2000/01/rdf-schema#label	RAF1 gene
gptkbp:interactsWith	gptkb:14-3-3_proteins gptkb:AKT1 gptkb:EGFR gptkb:ERK1/2 gptkb:FGFR gptkb:GSK3B gptkb:MAP2K1 gptkb:MAPK1 gptkb:MAPK3 gptkb:MEK1 gptkb:MEK2 gptkb:NF1 gptkb:PDGFR gptkb:PP2A gptkb:RAS_proteins gptkb:VEGFR gptkb:MAPK9 gptkb:MAPKAPK2 gptkb:MAPKAPK3 gptkb:MAPKAPK5 gptkb:PI3K gptkb:BAD gptkb:SRC gptkb:KIT gptkb:RET gptkb:MAP2K2 gptkb:MAPK14 gptkb:MAPK8 gptkb:DUSP6 gptkb:ARAF gptkb:BRAF gptkb:CRAF gptkb:PTEN gptkb:MET gptkb:p53 gptkb:HSP90 gptkb:BCL2 gptkb:KSR1 gptkb:MAPKAPK10 gptkb:MAPKAPK11 gptkb:MAPKAPK12 gptkb:MAPKAPK13 gptkb:MAPKAPK14 gptkb:MAPKAPK15 gptkb:MAPKAPK16 gptkb:MAPKAPK17 gptkb:MAPKAPK18 gptkb:MAPKAPK19 gptkb:MAPKAPK20 gptkb:MAPKAPK21 gptkb:MAPKAPK22 gptkb:MAPKAPK23 gptkb:MAPKAPK24 gptkb:MAPKAPK25 gptkb:MAPKAPK26 gptkb:MAPKAPK27 gptkb:MAPKAPK28 gptkb:MAPKAPK29 gptkb:MAPKAPK30 gptkb:MAPKAPK31 gptkb:MAPKAPK32 gptkb:MAPKAPK6 gptkb:MAPKAPK7 gptkb:MAPKAPK8 gptkb:MAPKAPK9 gptkb:MST2 gptkb:RASSF1A gptkb:CDC37 ASK1
gptkbp:involvedIn	gptkb:MAPK/ERK_signaling_pathway
gptkbp:locatedOnChromosome	3p25
gptkbp:mutationAssociatedWith	gain-of-function mutations cause developmental syndromes mutations can lead to oncogenic transformation
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Raf1
gptkbp:regulates	cell differentiation cell proliferation cell survival
gptkbp:UniProtID	gptkb:P04049
gptkbp:bfsParent	gptkb:RTK-RAS_pathway
gptkbp:bfsLayer	6