|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:RAC
gptkb:V-akt_murine_thymoma_viral_oncogene_homolog_1
gptkb:PKB
gptkb:Protein_kinase_B_alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Proteus_syndrome
prostate cancer
|
|
gptkbp:biologicalProcess
|
kinase activity
ATP binding
protein binding
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:encodes
|
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:Entrez_Gene_ID
|
207
ENSG00000142208
|
|
gptkbp:function
|
cell survival
signal transduction
cell growth
glucose metabolism
protein phosphorylation
apoptosis regulation
|
|
gptkbp:HGNC_ID
|
391
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT1
|
|
gptkbp:locatedOnChromosome
|
14q32.33
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:regulates
|
gptkb:FOXO1
gptkb:FOXO3
gptkb:FOXO4
gptkb:GAB2
gptkb:Mdm2
gptkb:PRAS40
gptkb:TSC1
gptkb:TSC2
gptkb:CREB
gptkb:GLUT4
gptkb:BAD
gptkb:p21
gptkb:Caspase-9
gptkb:IKK
gptkb:NF-kB
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:mTOR
gptkb:Cyclin_D1
gptkb:p53
gptkb:BCL2
gptkb:GSK-3_beta
gptkb:eNOS
gptkb:p27_Kip1
ASK1
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:PTEN
|
|
gptkbp:bfsLayer
|
5
|