|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:c-Raf
gptkb:proto-oncogene_serine/threonine-protein_kinase
|
|
gptkbp:discoveredBy
|
Ullrich et al.
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5894
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
signal transduction
serine/threonine-protein kinase activity
|
|
gptkbp:gene
|
gptkb:RAF1
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAF1 protein
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:AKT1_protein
gptkb:BCL2_protein
gptkb:RAS_protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
mitochondrion
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
|
|
gptkbp:phosphorylates
|
MAP2K1 (MEK1)
MAP2K2 (MEK2)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
activated by RAS binding
inhibited by phosphorylation at Ser259
regulated by 14-3-3 binding
|
|
gptkbp:significance
|
target for cancer therapy
target for RASopathies
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains kinase domain
contains regulatory domain
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:RAF1
|
|
gptkbp:bfsLayer
|
6
|