MEK1

URI: https://gptkb.org/entity/MEK1
GPTKB entity
Statements (23)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:MAP2K1
gptkb:MAPKK1
gptkbp:encodedBy gptkb:MAP2K1
gptkbp:enzymeCommissionNumber 2.7.12.2
gptkbp:fullName gptkb:Mitogen-activated_protein_kinase_kinase_1
gptkbp:function phosphorylates and activates ERK1/2
https://www.w3.org/2000/01/rdf-schema#label MEK1
gptkbp:inhibitedBy gptkb:trametinib
gptkb:cobimetinib
gptkb:selumetinib
gptkbp:locatedOnChromosome 15q22.31
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:Noonan_syndrome
gptkbp:organism gptkb:Homo_sapiens
gptkbp:pathway gptkb:MAPK/ERK_pathway
gptkbp:phosphorylates gptkb:ERK1
gptkb:ERK2
gptkbp:UniProtID Q02750
gptkbp:bfsParent gptkb:BRAF
gptkbp:bfsLayer 5