Statements (80)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
gptkb:Raf-1
gptkb:B-Raf MAPK |
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:form |
MEK1a
MEK1b |
| gptkbp:function |
mitogen-activated protein kinase kinase activity
dual specificity kinase |
| gptkbp:fuselage_material |
ERK1
ERK2 |
| gptkbp:has_role |
gptkb:neurodegenerative_diseases
inflammatory responses cancer progression neurogenesis |
| https://www.w3.org/2000/01/rdf-schema#label |
MEK1
|
| gptkbp:inhibitory_effect |
cell apoptosis
|
| gptkbp:initiated_by |
gptkb:Raf_kinase
Ras ERK1 ERK2 U0126 MEK inhibitors PD0325901 |
| gptkbp:interacts_with |
gptkb:Raf_kinase
MAPK1 MAPK3 |
| gptkbp:involved_in |
gptkb:developers
cell differentiation cell proliferation cell signaling |
| gptkbp:is_associated_with |
resistance to therapy
MAPK signaling |
| gptkbp:is_downregulated_in |
some cancers
|
| gptkbp:is_essential_for |
gptkb:embryonic_development
cell survival |
| gptkbp:is_expressed_in |
gptkb:Brain
various tissues lung |
| gptkbp:is_involved_in |
apoptosis
cell cycle regulation cell differentiation cellular homeostasis cellular stress response developmental processes immune response metabolic disorders wound healing neuroinflammation neuroplasticity stress response fibrosis cardiovascular diseases tumorigenesis tumor microenvironment cellular aging angiogenesis cell migration cellular repair mechanisms hormonal signaling cardiovascular development |
| gptkbp:is_linked_to |
cell migration
metastasis |
| gptkbp:is_overexpressed_in |
certain tumors
|
| gptkbp:is_part_of |
signal transduction pathways
MAPK/ ERK pathway |
| gptkbp:is_regulated_by |
growth factors
cytokines |
| gptkbp:is_similar_to |
gptkb:MEK2
|
| gptkbp:is_studied_in |
drug development
|
| gptkbp:is_targeted_at |
therapeutic agents
MEK inhibitors |
| gptkbp:located_in |
cytoplasm
|
| gptkbp:orthologs |
MEK1 in mice
|
| gptkbp:part_of |
MAPK/ ERK pathway
|
| gptkbp:promoter |
MAP2 K1
|
| gptkbp:regulates |
cell proliferation
|
| gptkbp:weight |
approximately 45 k Da
|
| gptkbp:bfsParent |
gptkb:Selumetinib
|
| gptkbp:bfsLayer |
5
|