14-3-3 proteins

GPTKB entity

Statements (56)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:binds phosphoserine-containing proteins
phosphothreonine-containing proteins
gptkbp:discoveredBy gptkb:Moore_and_Perez
gptkbp:discoveredIn 1967
gptkbp:foundIn eukaryotes
gptkbp:function signal transduction
regulation of cell cycle
apoptosis regulation
https://www.w3.org/2000/01/rdf-schema#label 14-3-3 proteins
gptkbp:involvedIn gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
neurodegenerative diseases
cancer progression
neuronal development
cellular stress response
gptkbp:locale gptkb:nucleus
gptkb:cytoplasm
mitochondria
gptkbp:namedAfter chromatography fraction number
gptkbp:proteinFamily gptkb:YWHAB
gptkb:YWHAE
gptkb:YWHAG
gptkb:YWHAP
gptkb:YWHAS
gptkb:YWHAZ
gptkb:SFN
YWHAT
gptkbp:regulates gptkb:CDC25_phosphatases
gptkb:glycogen_synthase_kinase_3
gptkb:protein_kinase_C
gptkb:p53_protein
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
apoptosis
transcription
metabolism
ion channels
RAF kinases
cytoskeletal dynamics
membrane trafficking
cell cycle checkpoints
gptkbp:significance implicated in cancer
biomarker for Creutzfeldt-Jakob disease
implicated in Alzheimer's disease
implicated in Parkinson's disease
implicated in schizophrenia
gptkbp:structure alpha-helical
dimeric
gptkbp:bfsParent gptkb:NEDD4-1
gptkb:PRAS40
gptkb:serine/threonine-protein_kinase_B-raf
gptkb:FOXO_transcription_factors
gptkb:RAF1
gptkb:Ras_signaling_pathway
gptkbp:bfsLayer 6