|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GRP94
gptkb:HSP86
gptkb:HSPC
gptkb:TRAP1
|
|
gptkbp:discoveredBy
|
gptkb:Ferruccio_Ritossa
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:EC_number
|
3.6.4.10
|
|
gptkbp:family
|
heat shock protein family
|
|
gptkbp:fullName
|
gptkb:Heat_Shock_Protein_90
|
|
gptkbp:function
|
protein folding
protein degradation
molecular chaperone
stabilization of proteins
|
|
gptkbp:gene
|
gptkb:HSP90
gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
|
|
gptkbp:GO_term
|
GO:0005524
GO:0006457
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSP90
|
|
gptkbp:inhibitedBy
|
gptkb:17-AAG
gptkb:geldanamycin
gptkb:radicicol
|
|
gptkbp:interactsWith
|
gptkb:HSP70
gptkb:AHA1
gptkb:CDC37
client proteins
p23
|
|
gptkbp:locatedOnChromosome
|
gptkb:12q24.31_(HSP90B1)
gptkb:14q32.33_(HSP90AA1)
gptkb:6p21.1_(HSP90AB1)
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:requires
|
cell survival
signal transduction
cell cycle control
protein homeostasis
|
|
gptkbp:role
|
gptkb:cancer
infectious diseases
neurodegenerative diseases
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:bfsParent
|
gptkb:HSP_gene_family
gptkb:aryl_hydrocarbon_receptor_(AhR)
gptkb:CHIP
|
|
gptkbp:bfsLayer
|
6
|