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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:abbreviation
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gptkb:Platelet-derived_growth_factor_receptor
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
gptkb:chronic_myelomonocytic_leukemia
|
|
gptkbp:binds
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gptkb:platelet-derived_growth_factor_(PDGF)
|
|
gptkbp:category
|
gptkb:receptor_tyrosine_kinase
cell signaling protein
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:downstreamOf
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gptkb:PLCĪ³_pathway
gptkb:PI3K/AKT_pathway
gptkb:RAS/MAPK_pathway
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_2.7.10.1
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor_receptor
|
|
gptkbp:function
|
cell surface tyrosine kinase receptor
|
|
gptkbp:gene
|
gptkb:PDGFRA
gptkb:PDGFRB
|
|
gptkbp:hasIsoform
|
gptkb:PDGFR-beta
gptkb:PDGFR-alpha
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFR
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:gastrointestinal_stromal_tumor
hypereosinophilic syndrome
myeloproliferative neoplasms
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:role
|
cell differentiation
cell proliferation
embryonic development
wound healing
angiogenesis
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:target
|
gptkb:imatinib
gptkb:sunitinib
gptkb:crenolanib
|
|
gptkbp:UniProtID
|
P09619 (PDGFRB)
P16234 (PDGFRA)
|
|
gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:bfsLayer
|
5
|