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gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
cytokines
growth factors
hormones
|
|
gptkbp:alsoKnownAs
|
gptkb:RTK-RAS-RAF-MEK-ERK_pathway
|
|
gptkbp:component
|
gptkb:EGFR
gptkb:ERK1
gptkb:MEK1
gptkb:KRAS
gptkb:BRAF
gptkb:GRB2
gptkb:SOS1
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:function
|
cell differentiation
cell proliferation
cell survival
cell growth
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RTK-RAS pathway
|
|
gptkbp:involves
|
gptkb:RAS_proteins
ERK kinases
MEK kinases
RAF kinases
receptor tyrosine kinases (RTKs)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:CBL_gene
gptkb:EGFR_gene
gptkb:HRAS_gene
gptkb:LZTR1_gene
gptkb:MAP2K1_gene
gptkb:MAP2K2_gene
gptkb:MAPK1_gene
gptkb:MAPK3_gene
gptkb:MRAS_gene
gptkb:NF1_gene
gptkb:NRAS_gene
gptkb:PPP1CB_gene
gptkb:PTPN11_gene
gptkb:RAF1_gene
gptkb:RASA1_gene
gptkb:RIT1_gene
gptkb:SHOC2_gene
gptkb:SOS1_gene
gptkb:SOS2_gene
gptkb:SPRED1_gene
gptkb:BRAF_gene
gptkb:KRAS_gene
|
|
gptkbp:regulates
|
apoptosis
gene expression
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
gptkb:RAF_inhibitors
tyrosine kinase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:KRAS
|
|
gptkbp:bfsLayer
|
5
|