|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK2
gptkb:Mitogen-activated_protein_kinase_1
gptkb:p42MAPK
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:encodedBy
|
gptkb:MAPK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100030
5594
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK1
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:interactsWith
|
gptkb:MAP2K1
gptkb:MAPK3
gptkb:ELK1
gptkb:c-Myc
gptkb:MAP2K2
gptkb:DUSP6
gptkb:p53
gptkb:RSK1
gptkb:c-Fos
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
cell proliferation
differentiation
cell cycle progression
transcription regulation
|
|
gptkbp:locatedOnChromosome
|
chromosome 22
22q11.22
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:molecularWeight
|
approximately 42 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk1
|
|
gptkbp:PDB
|
gptkb:2ERK
1TVO
3SA0
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:regulates
|
apoptosis
cell survival
transcription factors
cellular response to growth factors
|
|
gptkbp:substrate
|
gptkb:MAP2K1
gptkb:MAP2K2
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:ERK
gptkb:HRAS1
gptkb:MAPK_signaling_pathway
gptkb:RASH_HUMAN
gptkb:extracellular_signal-regulated_kinase
gptkb:3265_(HRAS)
gptkb:KEGG:_hsa04014
gptkb:P01112_(HRAS)
|
|
gptkbp:bfsLayer
|
6
|