|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MEK2
gptkb:PRKMK2
gptkb:MKK2
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:encodes
|
gptkb:MEK2
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000126934
5605
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_2
|
|
gptkbp:function
|
phosphorylates and activates MAP kinases
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K2
|
|
gptkbp:inhibitedBy
|
gptkb:U0126
gptkb:PD0325901
|
|
gptkbp:kinase_activity
|
serine/threonine-protein kinase
|
|
gptkbp:length
|
400 amino acids
|
|
gptkbp:locatedOnChromosome
|
19
|
|
gptkbp:location
|
gptkb:19p13.3
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:OMIM
|
601263
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Map2k2
gptkb:zebrafish_map2k2a
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:PDB
|
gptkb:3SLS
|
|
gptkbp:phosphorylates
|
gptkb:BRAF
gptkb:RAF1
Ser218
Ser222
|
|
gptkbp:proteinFamily
|
gptkb:MAP_kinase_kinase_family
|
|
gptkbp:regulates
|
gptkb:MAPK1
gptkb:MAPK3
|
|
gptkbp:relatedTo
|
apoptosis
cell proliferation
differentiation
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
|
gptkbp:substrate
|
gptkb:MAPK1
gptkb:MAPK3
|
|
gptkbp:symbol
|
gptkb:MAP2K2
|
|
gptkbp:UniProtID
|
P36507
|
|
gptkbp:bfsParent
|
gptkb:B-RAF1
gptkb:MEK2
gptkb:serine/threonine-protein_kinase_B-raf
gptkb:MAPK_signaling_pathway
gptkb:3265_(HRAS)
gptkb:KEGG:_hsa04014
gptkb:P01112_(HRAS)
|
|
gptkbp:bfsLayer
|
6
|