|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:RAF1
|
|
gptkbp:discoveredBy
|
gptkb:Hartmut_Beug
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-RAF
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:location
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:A-RAF
gptkb:B-RAF
|
|
gptkbp:PDB
|
gptkb:3OMV
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:target
|
gptkb:sorafenib
gptkb:regorafenib
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:RAFB1
gptkb:RAF1
|
|
gptkbp:bfsLayer
|
6
|