|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:cell_division_cycle_37_homolog
p50cdc37
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
signal transduction
cell cycle regulation
protein folding
protein binding
chaperone binding
|
|
gptkbp:discoveredBy
|
gptkb:yeast
|
|
gptkbp:encodes
|
gptkb:Hsp90_co-chaperone_Cdc37
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000122026
11140
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
protein kinase chaperone
|
|
gptkbp:gene
|
gptkb:CDC37
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1726
|
|
gptkbp:high_expression_in
|
gptkb:testis
brain
liver
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDC37
|
|
gptkbp:interactsWith
|
gptkb:AKT1
gptkb:EGFR
gptkb:MAPK1
gptkb:SRC
gptkb:RAF1
gptkb:CDK4
gptkb:CDK6
gptkb:STK11
gptkb:HSP90AA1
|
|
gptkbp:length
|
378
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
gptkb:chromosome_19
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
cell cycle arrest
defective kinase signaling
|
|
gptkbp:OMIM
|
604439
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdc37
|
|
gptkbp:orthologInYeast
|
gptkb:Cdc37p
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
protein kinases
|
|
gptkbp:requires
|
Hsp90 chaperone function
stability of protein kinases
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q16543
|
|
gptkbp:bfsParent
|
gptkb:RAF1_gene
gptkb:HSP90
|
|
gptkbp:bfsLayer
|
7
|