|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
RASSF1 isoform A
Ras association domain-containing protein 1 isoform A
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
liver cancer
prostate cancer
|
|
gptkbp:discoveredBy
|
Dallol et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:domain
|
Ras association domain
SARAH domain
|
|
gptkbp:encodedBy
|
RASSF1 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000104904
11186
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:HGNC_ID
|
HGNC:9872
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RASSF1A
|
|
gptkbp:interactsWith
|
gptkb:MST1
gptkb:MOAP1
gptkb:MST2
gptkb:DNMT1
C19ORF5
|
|
gptkbp:involvedIn
|
apoptosis
cell cycle regulation
microtubule stabilization
|
|
gptkbp:length
|
340 amino acids
|
|
gptkbp:locatedIn
|
human chromosome 3p21.3
|
|
gptkbp:lossOfFunction
|
associated with tumorigenesis
|
|
gptkbp:methylationStatus
|
frequently hypermethylated in cancers
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:cyclin_D1
gptkb:p53
gptkb:Hippo_signaling_pathway
cell proliferation
DNA repair
cell migration
microtubule dynamics
cell adhesion
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
microtubules
|
|
gptkbp:UniProtID
|
Q9NS23-1
|
|
gptkbp:bfsParent
|
gptkb:RAF1_gene
gptkb:RASSF1
|
|
gptkbp:bfsLayer
|
7
|