|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:biologicalProcess
|
gptkb:Wnt_signaling_pathway
cell differentiation
apoptotic process
glycogen metabolic process
insulin signaling pathway
protein serine/threonine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:encodedBy
|
gptkb:GSK3B_gene
|
|
gptkbp:Entrez_Gene_ID
|
2932
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.26
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase_3_beta
|
|
gptkbp:gene
|
gptkb:GSK3B
|
|
gptkbp:hasParalog
|
gptkb:GSK3A
|
|
gptkbp:HGNC_ID
|
4617
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK3B
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:CHIR99021
lithium
|
|
gptkbp:length
|
420 amino acids
|
|
gptkbp:locatedOnChromosome
|
3
3q13.33
|
|
gptkbp:memberOf
|
gptkb:GSK3_family
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:OMIM
|
605004
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Gsk3b
|
|
gptkbp:PDB
|
gptkb:1Q4L
gptkb:6Y9S
4AFJ
|
|
gptkbp:phosphorylates
|
Ser9
Tyr216
|
|
gptkbp:regulates
|
gptkb:glycogen_synthase
gptkb:beta-catenin
apoptosis
gene expression
cell cycle
microtubule dynamics
|
|
gptkbp:substrate
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
|
|
gptkbp:UniProtID
|
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1
|
|
gptkbp:bfsLayer
|
5
|