|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:JNK1
gptkb:c-Jun_N-terminal_kinase_1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
inflammatory diseases
|
|
gptkbp:discoveredBy
|
gptkb:Michael_Karin
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:Entrez_Gene_ID
|
5599
ENSG00000107643
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_8
|
|
gptkbp:function
|
regulates apoptosis
regulates transcription
involved in stress-activated protein kinase signaling pathway
regulates cellular proliferation
regulates differentiation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6881
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK8
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
gptkb:JNK-IN-8
|
|
gptkbp:interactsWith
|
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:JUN
gptkb:DUSP1
gptkb:FOS
gptkb:TP53
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
cellular response to stress
apoptosis pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:JNK_subfamily
|
|
gptkbp:numberOfTranscripts
|
multiple
|
|
gptkbp:OMIM
|
601158
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk8
|
|
gptkbp:PDB
|
gptkb:4AWI
gptkb:4QTD
3V6S
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:ELK1
gptkb:c-Jun
|
|
gptkbp:regulates
|
cell survival
transcription factors
cell death
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P45983
|
|
gptkbp:bfsParent
|
gptkb:P42680
gptkb:JNK_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|