|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ERBB1
gptkb:HER1
mENA
|
|
gptkbp:binds
|
gptkb:epidermal_growth_factor
gptkb:transforming_growth_factor_alpha
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:encodes
|
gptkb:epidermal_growth_factor_receptor_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
1956
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
brain
colon
epithelial tissues
|
|
gptkbp:family
|
gptkb:ErbB_family
|
|
gptkbp:fullName
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
signal transduction
cell differentiation regulation
cell proliferation regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EGFR
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
7
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
170 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Egfr
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:PDB
|
1M17
2GS6
4KRL
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:regulates
|
apoptosis
angiogenesis
cell growth
cell migration
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
|
|
gptkbp:UniProtID
|
gptkb:P00533
|
|
gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:bfsLayer
|
5
|