|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:associated_with
|
gptkb:Oncology
resistance to therapy
poor prognosis
increased metastasis
tumor recurrence
|
|
gptkbp:chromosome_location
|
7p11.2
|
|
gptkbp:clinical_trial
|
biomarker for targeted therapy
combination therapy trials
targeted therapy trials
|
|
gptkbp:discovered_by
|
gptkb:Stanley_Cohen
|
|
gptkbp:ecological_role
|
gptkb:Oncology
head and neck cancer
|
|
gptkbp:family
|
gptkb:Erb_B_family
|
|
gptkbp:full_name
|
gptkb:Epidermal_Growth_Factor_Receptor
|
|
gptkbp:function
|
cell signaling
|
|
gptkbp:genetic_studies
|
resistance mutations
activating mutations
L858 R
T790 M
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EGFR
|
|
gptkbp:inhibitor_type
|
monoclonal antibodies
tyrosine kinase inhibitors
|
|
gptkbp:initiated_by
|
gptkb:Erlotinib
gptkb:Gefitinib
|
|
gptkbp:interacts_with
|
gptkb:STAT3
gptkb:SHC1
gptkb:GRB2
gptkb:SOS1
gptkb:PIK3_CA
|
|
gptkbp:involved_in
|
apoptosis regulation
cell differentiation
cell proliferation
tumorigenesis
|
|
gptkbp:is_expressed_in
|
overexpressed in tumors
high in colorectal cancer
high in breast cancer
high in glioblastoma
|
|
gptkbp:is_recognized_as
|
gptkb:1984
|
|
gptkbp:pathway
|
MAPK/ ERK pathway
PI3 K/ AKT pathway
|
|
gptkbp:promoter
|
gptkb:EGFR
|
|
gptkbp:related_products
|
gptkb:Epidermal_Growth_Factor
gptkb:Transforming_Growth_Factor-alpha
|
|
gptkbp:research_focus
|
cancer therapy
signal transduction
therapeutic strategies
drug resistance mechanisms
biomarker development
|
|
gptkbp:targets
|
monoclonal antibodies
small molecule inhibitors
|
|
gptkbp:type
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:bfsParent
|
gptkb:Oncology
|
|
gptkbp:bfsLayer
|
4
|