|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:hypoxia
oxidative stress
DNA damage
oncogene activation
|
|
gptkbp:alsoKnownAs
|
gptkb:TP53
|
|
gptkbp:degradedBy
|
gptkb:MDM2
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
regulatory domain
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:expressedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p53
|
|
gptkbp:inhibitedBy
|
gptkb:MDMX
gptkb:MDM2
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
gptkb:rhabdomyosarcoma
colorectal cancer
liver cancer
pancreatic cancer
brain cancer
bladder cancer
|
|
gptkbp:mutationFrequencyInHumanCancers
|
over 50%
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:C._elegans
gptkb:zebrafish
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:regulates
|
gptkb:CDKN1A
gptkb:FAS
gptkb:PERP
gptkb:BAX
gptkb:DDB2
gptkb:GADD45
gptkb:GDF15
gptkb:GLS2
gptkb:IGFBP3
gptkb:NOXA
gptkb:PIG3
gptkb:PUMA
gptkb:RRM2B
gptkb:SCO2
gptkb:SESN1
gptkb:SESN2
gptkb:TIGAR
gptkb:miR-145
gptkb:miR-192
gptkb:miR-194
gptkb:miR-215
gptkb:miR-34a
gptkb:miR-605
gptkb:p21
gptkb:DR5
gptkb:MDM2
gptkb:PTEN
gptkb:BCL2
apoptosis
DNA repair
metabolism
angiogenesis
cell cycle
senescence
BBC3
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:PTEN
|
|
gptkbp:bfsLayer
|
5
|