Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:Li-Fraumeni_syndrome |
| gptkbp:degraded_by |
ubiquitination
|
| gptkbp:discovered_by |
gptkb:David_Lane
|
| gptkbp:first_characterized_in |
gptkb:1979
|
| gptkbp:form |
gptkb:p53α
gptkb:p53_R2 p53β p53γ Δ40p53 |
| gptkbp:forms_complex_with |
p300
CBP |
| gptkbp:function |
tumor suppressor
|
| gptkbp:genetic_studies |
associated with cancer
|
| https://www.w3.org/2000/01/rdf-schema#label |
p53
|
| gptkbp:initiated_by |
stress signals
MDM2 inhibitors |
| gptkbp:interacts_with |
gptkb:CHK2
gptkb:GADD45 gptkb:MDM2 ATM p21 BAX |
| gptkbp:involved_in |
cellular stress response
developmental processes immune response autoimmune diseases metabolic syndrome cardiovascular diseases cellular senescence tumorigenesis cellular differentiation genomic stability chronic inflammation aging process viral infections neurodegeneration cell cycle arrest endocrine signaling metabolism regulation transcriptional regulation cellular response to DNA damage cellular response to hypoxia cellular response to oxidative stress neoplastic transformation angiogenesis regulation apoptotic signaling pathway metastasis suppression reproductive system regulation stem cell regulation |
| gptkbp:is_expressed_in |
many tissues
|
| gptkbp:is_targeted_at |
cancer therapies
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promoter |
gptkb:TP53
|
| gptkbp:regulates |
gene expression
|
| gptkbp:role |
DNA repair
apoptosis cell cycle regulation |
| gptkbp:stabilized_by |
DNA damage
|
| gptkbp:bfsParent |
gptkb:HOT3
gptkb:c-Myc gptkb:MDM2 gptkb:TP53 |
| gptkbp:bfsLayer |
5
|