Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:c-Myc
gptkb:AKT gptkb:ATM_protein gptkb:ATR_protein gptkb:Adult_T-cell_leukemia |
| gptkbp:associated_with |
gptkb:healthcare_organization
gptkb:Li-Fraumeni_syndrome |
| gptkbp:damage |
ubiquitination
|
| gptkbp:discovered_by |
gptkb:David_Lane
|
| gptkbp:established |
stress signals
MD M2 inhibitors |
| gptkbp:first_described_by |
gptkb:1979
|
| gptkbp:form |
gptkb:p53α
gptkb:p53_R2 p300 CBP p53β p53γ Δ40p53 |
| gptkbp:function |
tumor suppressor
|
| gptkbp:genetic_diversity |
associated with cancer
|
| https://www.w3.org/2000/01/rdf-schema#label |
p53
|
| gptkbp:interacts_with |
ATM
p21 BAX CH K2 GAD D45 MD M2 |
| gptkbp:is_aimed_at |
cancer therapies
|
| gptkbp:is_countered_by |
DNA damage
|
| gptkbp:is_involved_in |
cellular stress response
developmental processes immune response autoimmune diseases metabolic syndrome cardiovascular diseases cellular senescence tumorigenesis cellular differentiation genomic stability chronic inflammation aging process viral infections neurodegeneration cell cycle arrest endocrine signaling metabolism regulation transcriptional regulation cellular response to DNA damage cellular response to hypoxia cellular response to oxidative stress neoplastic transformation angiogenesis regulation apoptotic signaling pathway metastasis suppression reproductive system regulation stem cell regulation |
| gptkbp:is_represented_in |
many tissues
|
| gptkbp:location |
gptkb:physicist
|
| gptkbp:promoter |
T P53
|
| gptkbp:regulates |
gene expression
|
| gptkbp:role |
DNA repair
apoptosis cell cycle regulation |