|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:MAP2K1
gptkb:MAP2K2
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK1
gptkb:p44MAPK
|
|
gptkbp:encodedBy
|
gptkb:MAPK3_gene
|
|
gptkbp:Entrez_Gene_ID
|
5595
ENSG00000102882
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.24
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_3
|
|
gptkbp:function
|
signal transduction
regulation of cell proliferation
regulation of transcription
regulation of differentiation
regulation of development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6877
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK3
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:interactsWith
|
gptkb:MAP2K1
gptkb:MAPK1
gptkb:ELK1
gptkb:MAP2K2
gptkb:DUSP6
gptkb:MAPT
gptkb:MYC
gptkb:STAT3
|
|
gptkbp:length
|
379 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:ERK_subfamily
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
neurodevelopmental disorders
|
|
gptkbp:OMIM
|
601795
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
gptkb:EGF_signaling_pathway
gptkb:FGF_signaling_pathway
insulin signaling pathway
|
|
gptkbp:PDB
|
2ZOQ
|
|
gptkbp:phosphorylates
|
gptkb:ELK1
gptkb:MAPT
gptkb:MYC
gptkb:STAT3
|
|
gptkbp:RefSeq
|
NM_002746
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:16p11.2
gptkb:ERK
gptkb:MAPK_signaling_pathway
gptkb:RASH_HUMAN
gptkb:extracellular_signal-regulated_kinase
gptkb:KEGG:_hsa04014
|
|
gptkbp:bfsLayer
|
6
|