Statements (85)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
gptkb:Raf_kinase
MAPK |
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:function |
mitogen-activated protein kinase kinase activity
dual specificity kinase |
| gptkbp:fuselage_material |
ERK1
ERK2 |
| gptkbp:has_role |
apoptosis regulation
cell differentiation cell proliferation neurogenesis |
| https://www.w3.org/2000/01/rdf-schema#label |
MEK2
|
| gptkbp:inhibitory_effect |
cell apoptosis
|
| gptkbp:initiated_by |
gptkb:Ras_protein
Ras ERK1 ERK2 U0126 MEK inhibitors PD0325901 |
| gptkbp:interacts_with |
gptkb:Raf_kinase
MAPK1 MAPK3 |
| gptkbp:involved_in |
gptkb:developers
cell signaling |
| gptkbp:is_associated_with |
various diseases
MAPK signaling |
| gptkbp:is_essential_for |
gptkb:embryonic_development
cell cycle progression |
| gptkbp:is_expressed_in |
gptkb:Brain
various tissues lung |
| gptkbp:is_involved_in |
cell differentiation
cellular homeostasis cellular metabolism cellular stress response immune response inflammation wound healing muscle development stress response cellular proliferation cellular senescence tumorigenesis cell survival cellular aging cellular differentiation cancer progression neurogenesis angiogenesis tissue repair cell migration cellular adhesion neuronal development cellular communication endocrine signaling metabolic regulation cellular response to cytokines cellular response to hormones cellular stress adaptation cellular response to growth factors cellular response to stimuli apoptotic signaling cardiovascular development cellular motility differentiation of stem cells reproductive signaling cellular response to environmental stress |
| gptkbp:is_linked_to |
cell migration
|
| gptkbp:is_part_of |
signal transduction pathways
MAPK/ ERK pathway |
| gptkbp:is_regulated_by |
growth factors
cytokines |
| gptkbp:is_studied_in |
biomedical research
|
| gptkbp:is_targeted_at |
cancer therapies
MEK inhibitors |
| gptkbp:located_in |
cytoplasm
|
| gptkbp:orthologs |
MEK2 in mice
|
| gptkbp:part_of |
MAPK/ ERK pathway
|
| gptkbp:promoter |
MAP2 K2
|
| gptkbp:regulates |
cell proliferation
|
| gptkbp:weight |
approximately 45 k Da
|
| gptkbp:bfsParent |
gptkb:Selumetinib
|
| gptkbp:bfsLayer |
5
|